The risk of diabetes development in long-term observation of patients with acute hyperglycaemia during myocardial infarction.

Background: Acute hyperglycemia in patients with myocardial infarction is an unfavorable predictive factor. However, there are limited data regarding the relationship between acute hyperglycemia and the incidence of new onsets diabetes in long-term observation.

Aim: We studied the relationship between admission glycemia in patients with myocardial infarction and the future development of diabetes.

Model of the distribution of diastolic left ventricular posterior wall thickness in healthy adults and its impact on the behavior of a string of virtual cardiomyocytes.

Correlation of the thickness of the left ventricular posterior wall (LVPWd) with various parameters, including age, gender, weight and height, was investigated in this study using regression models. Multicenter derived database comprised over 4,000 healthy individuals. The developed models were further utilized in the in vitro-in vivo (IVIV) translation of the drug cardiac safety data with use of the mathematical model of human cardiomyocytes operating at the virtual healthy population level.

Myocardial infarction caused by pharmacological substances - case description and literature review.

Myocardial infarction (MI) is most commonly caused by atherosclerosis and/or inflammatory processes of coronary artery walls. The consequence of those phenomena is instability of the atherosclerotic plaque, activation of the coagulation cascade and thrombus formation which occludes the lumen of the vessel. Vasospasm and microembolisation may participate in MI pathogenesis.

The effects of acute hyperglycaemia on the in-hospital and long-term prognosis in patients with an acute coronary syndrome--a pilot study.

Background: Acute hyperglycaemia is an adverse prognostic factor in patients with acute coronary syndrome (ACS). It is unclear whether these negative effects apply equally to patients with diabetes mellitus (DM) and non-DM patients.

Aim: To evaluate the short-term (in-hospital) and long-term (four-year) prognostic value of acute hyperglycaemia in ACS patients with or without DM.