Publications by authors named "Maryann Arnstein"
Mitochondrial stress has been widely observed in diabetic kidney disease (DKD). Cyclophilin D (CypD) is a functional component of the mitochondrial permeability transition pore (mPTP) which allows the exchange of ions and solutes between the mitochondrial matrix to induce mitochondrial swelling and activation of cell death pathways. CypD has been successfully targeted in other disease contexts to improve mitochondrial function and reduced pathology.
View Article and Find Full Text PDFHeat shock protein (HSP) HSP27, HSP60, HSP70, and HSP90 are induced by cellular stresses and play a key role in cytoprotection. Both hyperglycemia and glomerular hypertension are crucial determinants in the pathogenesis of diabetic nephropathy and impose cellular stresses on renal target cells. We studied both the expression and the phosphorylation state of HSP27, HSP60, HSP70, and HSP90 in vivo in rats made diabetic with streptozotocin and in vitro in mesangial cells and podocytes exposed to either high glucose or mechanical stretch.
View Article and Find Full Text PDFArticle Synopsis
- - Studies on diabetic Sprague Dawley rats evaluated the impact of alagebrium (an AGE inhibitor) and ramipril (an ACE inhibitor) on renal function and various mediators of diabetic kidney disease over a 32-week period.
- - While both treatments individually reduced albuminuria, combining them did not yield additional benefits; however, they both effectively lowered circulating levels of carboxymethyllysine, a harmful AGE, without affecting renal levels.
- - The results indicate that while both treatments have unique effects on diabetes-related kidney issues, they share some similar outcomes, suggesting potential pathways for developing future therapies targeting diabetic nephropathy.