Cognitive cues and visually induced motion sickness.

Background: The importance of cognitive processing of orientation cues in visually induced motion sickness and vection is often overlooked. Upright versus inverted visual scenes containing cues of different levels of salience were compared.

Methods: Panoramic scenes of 360 degrees were projected in the visual equivalent to the nauseogenic situation of rotating about an axis tilted from the vertical with a field of view of 84 degrees rotating at 0.

Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein.

Chemical genetics is an emerging approach to investigate the biology of host-pathogen interactions. We screened several inhibitors of ATP-dependent DNA motors and detected the gyrase B inhibitor coumermycin A1 (C-A1) as a potent antiretroviral. C-A1 inhibited HIV-1 integration and gene expression from acutely infected cell, but the two activities mapped to distinct targets.