Molecular and Biochemical Evidences for Beneficial Effects of Zinc Oxide Nanoparticles in Modulation of Chlorpyrifos Toxicity in Human Lymphocytes.

Chlorpyrifos (CP), an acetylcholinesterase (AChE) inhibitor, is used throughout the world as an insecticide in agriculture and an eradicating agent for termites around homes. In the present study, we examined the protective role of zinc oxide nanoparticles (ZnO NPs) in human CP-treated lymphocytes. Lymphocytes isolated by Ficoll and exposed to 75 µg/mL CP either alone or in combination with logarithmic doses of ZnO NPs (0/1, 1, 10, 100 µg/mL).

Protective Effect of Selenium-Based Medicines on Toxicity of Three Common Organophosphorus Compounds in Human Erythrocytes In Vitro.

Objective: Organophosphorus (OP) compounds are used to control pests, however they can reach the food chain and enter the human body causing serious health problems by means of acetylcholinesterase (AChE) inhibition and oxidative stress (OS). Among the OPs, chlorpyrifos (CHP), malathion (MAL), and diazinon (DIA) are commonly used for commercial extermination purposes, in addition to veterinary practices, domestic, agricul- ture and public health applications. Two new recently registered medicines that contain selenium and other antioxidants, IMOD and angipars (ANG), have shown beneficial ef- fects for OS related disorders.

Survival benefits of dexmedetomidine used for sedating septic patients in intensive care setting: A systematic review.

Purpose: The aim of this systematic review was to evaluate the effectiveness and safety of dexmedetomidine used for sedation of patients with sepsis.

Methods: We searched Medline, Scopus, TRIP and CENTRAL, DART, OpenGrey, and ProQuest without applying any language filter up to July 15, 2015. Two of the authors independently reviewed search results for irrelevant and duplicate studies and extracted data and assessed methodological quality of the studies.