Preparation of magnetic molecularly imprinted polymer for dispersive solid-phase extraction of valsartan and its determination by high-performance liquid chromatography: Box-Behnken design.

In this work, core/shell magnetic molecularly imprinted polymer nanoparticles were synthesized for extraction and pre-concentration of valsartan from different samples and then it was measured with high-performance liquid chromatography. For preparation of molecularly imprinted polymer nanoparticles, Fe O nanoparticles were coated with tetraethyl orthosilicate and then functionalized with 3-(trimethoxysilyl) propyl methacrylate. In the next step, molecularly imprinted polymer nanoparticles were synthesized under reflux and distillation conditions via polymerization of methacrylic acid, valsartan (as a template), azobisisobutyronitrile and ethylene glycol dimethacrylate as cross linking.