The Association of Social Determinants of Health on Monitoring for Disease Progression Among Patients With Primary Open-Angle Glaucoma.

Purpose: To examine the association of race, ethnicity, and other social determinants of health (SDH) on receipt of optic nerve (ON) evaluation in accordance with National Quality Forum (NQF) and the American Academy of Ophthalmology (AAO) guideline-based metrics.

Methods: This was a retrospective cohort study consisting of 13,582 patients with POAG receiving care across 12 tertiary care health. The odds of receiving ≥1 ON evaluations to monitor for glaucoma progression over 45 months of follow-up was evaluated.

Race, Social Determinants of Health, and the Quality of Diabetic Eye Care.

Importance: Besides race, little is known about how other social determinants of health (SDOH) affect quality of diabetic eye care.

Objective: To evaluate the association between multiple SDOH and monitoring for diabetic retinopathy (DR) in accordance with clinical practice guidelines (CPGs).

Design, Setting, And Participants: This cohort study was conducted in 11 US medical centers and included adult patients (18-75 years old) with diabetes.

Single-cell analysis reveals inflammatory interactions driving macular degeneration.

Due to commonalities in pathophysiology, age-related macular degeneration (AMD) represents a uniquely accessible model to investigate therapies for neurodegenerative diseases, leading us to examine whether pathways of disease progression are shared across neurodegenerative conditions. Here we use single-nucleus RNA sequencing to profile lesions from 11 postmortem human retinas with age-related macular degeneration and 6 control retinas with no history of retinal disease. We create a machine-learning pipeline based on recent advances in data geometry and topology and identify activated glial populations enriched in the early phase of disease.

Herbal Medicines in Glaucoma Treatment.

Glaucoma is the leading cause of irreversible blindness worldwide. Optimizing treatment is important to protecting vision. The current standard of therapy for glaucoma involves lowering the intraocular pressure (IOP) through medical, laser, and/or surgical therapy.

Polyester vascular patches acquire arterial or venous identity depending on their environment.

Polyester is commonly used in vascular surgery for patch angioplasty and grafts. We hypothesized that polyester patches heal by infiltration of arterial or venous progenitor cells depending on the site of implantation. Polyester patches were implanted into the Wistar rat aorta or inferior vena cava and explanted on day 7 or 30.