Is Serum TGF-β1 and TGF-β2 levels Correlated to Children with Autism Intensity?

Objective: Transforming growth factor-beta (TGF-β), a group of multifunctional growth factors, plays an important role in the neuron survival and neurodevelopmental functions. Some studies have evaluated the correlation between TGF-β1 and TGF-β2 abnormalities and autism spectrum disorders. In this study, we compared the TGF-β1 and TGF-β2 levels between autistic and intellectually normal individuals.

Transforming growth factor beta 1 869T/C and 915G/C polymorphisms and risk of autism spectrum disorders.

Background: Transforming growth factor-β1 (TGF-β1) has been found to play a crucial role in early central nervous system development. Several studies have illustrated decreased TGF-β1 levels in sera and brains of autistic children. Two point mutations in the TGF-β1 signal peptide at 869T/C and 915G/C have been reported to influence TGF-β1 expression.

Measurement of Serum Superoxide Dismutase and Its Relevance to Disease Intensity Autistic Children.

Background: Autism is a pervasive disorder and its prevalence increased in recent surveys. An estimated 1 out of every 88 children is affected by autism. Autism disorder symptoms appear before the age of three.

The evaluation of food allergy on behavior in autistic children.

Background: Despite many efforts, the etiology of autism remains unknown. Food allergy has been suggested as a pathogenic factor in Autism Spectrum Disorder (ASD). Our aim in this study was to determine whether food allergy could be considered as a risk factor for autistic children.