Evaluation of debridement effects of bromelain-loaded sodium alginate nanoparticles incorporated into chitosan hydrogel in animal models.

Objectives: Bromelain, a mixture of proteolytic enzymes from pineapple () is known as a potential debriding agent in burn treatment. In this research, the debridement efficiency of chitosan hydrogel loaded by sodium alginate-chitosan nanoparticles (NPs) containing bromelain (Br 10%-AG-CS NPs) was evaluated in animal models.

Materials And Methods: The NPs were prepared using the ionic gelation technique and their properties were identified.

Evaluation of the osteogenic potential of crocin-incorporated collagen scaffold on the bone marrow mesenchymal stem cells.

Objective: The present study aimed to evaluate the effect of crocin (CRO)-loaded collagen (COL) scaffold on the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (BM-MSCs).

Significance: Different studies have been conducted to develop an efficient strategy to accelerate and improve the recovery process of bone defects. It was shown that CRO, extracted from saffron, could induce osteogenic differentiation of rat BM-MSCs.