Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review.

Interfaces with peripheral nerves have been widely developed to enable bioelectronic control of neural activity. Peripheral nerve neuromodulation shows great potential in addressing motor dysfunctions, neurological disorders, and psychiatric conditions. The integration of high-density neural electrodes with stimulation and recording circuits poses a challenge in the design of neural interfaces.

A multi-channel stimulator with an active electrode array implant for vagal-cardiac neuromodulation studies.

Background: Implantable vagus nerve stimulation is a promising approach for restoring autonomic cardiovascular functions after heart transplantation. For successful treatment a system should have multiple electrodes to deliver precise stimulation and complex neuromodulation patterns.

Methods: This paper presents an implantable multi-channel stimulation system for vagal-cardiac neuromodulation studies in swine species.

A Fully Implantable Opto-Electro Closed-Loop Neural Interface for Motor Neuron Disease Studies.

This paper presents a fully implantable closed-loop device for use in freely moving rodents to investigate new treatments for motor neuron disease. The 0.18 μm CMOS integrated circuit comprises 4 stimulators, each featuring 16 channels for optical and electrical stimulation using arbitrary current waveforms at frequencies from 1.

Time Stamp - A Novel Time-to-Digital Demodulation Method for Bioimpedance Implant Applications.

Bioimpedance analysis is a noninvasive and inexpensive technology used to investigate the electrical properties of biological tissues. The analysis requires demodulation to extract the real and imaginary parts of the impedance. Conventional systems use complex architectures such as I-Q demodulation.