The lasting influence of parenting intervention on child behavior: findings from a randomized clinical trial using care for child development guidelines.

Background: Studies have investigated the role of different parenting intervention programs in the early development of children. Here we aimed to determine the long-term efficacy of Care for Child Development (CCD) guideline interventions on behavioral dimensions of children's development.

Methods: This randomized clinical trial took place at an outpatient public Pediatrics clinic in Isfahan, Iran from February 2020 to May 2024.

Exploring the Phenotypic Profile of Acute Flaccid Paralysis: Insights from a Third-Level Pediatric Emergency Room.

Objectives: Acute Flaccid Paralysis (AFP) in children can stem from a diverse array of potential diagnoses.

Materials & Methods: This retrospective study sought to diagnose children referred to a referral pediatric emergency unit with AFP between 2011 and 2016. The study gathered clinical observations, conducted stool and cerebrospinal fluid analyses, and assessed electrophysiological and imaging data.

A comprehensive investigation of the associations between tensor-based morphometry indices and executive functions, memory, language, and visuospatial abilities in patients in the Alzheimer's disease continuum.

Objectives: Based on the literature, tensor-based morphometry (TBM) parameters were related to neurocognitive functions such as memory, learning, language ability, and executive functions. The present study aims to evaluate the associations between TBM indices with executive functions, memory, language, and visuospatial abilities and the value of TBM in the clinical diagnosis of Alzheimer's disease (AD) among individuals with Alzheimer's disease continuum and mild cognitive impairment (MCI) from Alzheimer's Disease Neuroimaging Initiative (ADNI).

Methods: The authors used ADNI-memory (ADNI-MEM), ADNI-executive functions (ADNI-EF), ADNI-language (ADNI-LAN), and ADNI-visuospatial (ADNI-VS) composite scores.

An overview of early-onset cerebellar ataxia: a practical guideline.

Early onset ataxias (EOAs) are a heterogeneous group of rare neurological disorders that not only involve the central and peripheral nervous system but also involve other organs. They are mainly manifested by degeneration or abnormal development of the cerebellum occurring before the age of 25 years and typically the pattern of inheritance is autosomal recessive.The diagnosis of autosomal recessive cerebellar ataxias (ARCAs) is confirmed by the clinical, laboratory, electrophysiological examination, neuroimaging findings, and mutation analysis when the causative gene is detected.

Persian version of brief infant sleep questionnaire (BISQ): a psychometric evaluation.

Background: The high prevalence of sleep problems and their negative consequences on children and parents highlight the need to design early screening instruments to evaluate sleep problems in early childhood. We aimed to determine the validity and reliability of the Brief Infant Sleep Questionnaire (BISQ) among the Iranian population.

Methods And Materials: This study included 646 one-year-old infants by random sampling from the PERSIAN birth cohort study.

Phenotype and genotype heterogeneity of PLA2G6-associated neurodegeneration in a cohort of pediatric and adult patients.

Background: Phospholipase-associated neurodegeneration (PLAN) caused by mutations in the PLA2G6 gene is a rare neurodegenerative disorder that presents with four sub-groups. Infantile neuroaxonal dystrophy (INAD) and PLA2G6-related dystonia-parkinsonism are the main two subtypes. In this cohort, we reviewed clinical, imaging, and genetic features of 25 adult and pediatric patients harboring variants in the PLA2G6.

Efficacy and safety of miglustat in the treatment of GM2 gangliosidosis: A systematic review.

Background: Since the results of previous studies regarding the safety and efficacy of miglustat in GM2 gangliosidosis (GM2g) were inconsistent, we aimed to assess miglustat therapy in GM2g patients.

Methods: This study followed the latest version of PRISMA. We included the observational or interventional studies reporting GM2g patients under miglustat therapy by searching PubMed, Web of Science, and Scopus.

White matter tracts alterations underpinning reward and conflict processing.

Background: Reinforcement sensitivity theory (RST) is proposed as a neurobiological system that eventually led to emotion and motivation-based constructs of personality. Traditionally segmented into the behavioral activation system (BAS) and the behavioral inhibition system (BIS), RST is commonly used to describe personality and behavior. Although there have been studies linking gray matter alterations with BIS/BAS subscales, the role of white matter (WM) alterations is yet controversial.

Changes in Lifestyle Behaviors of Children and Adolescents during the COVID-19 Pandemic and the Impact on the Development of Non-Communicable Diseases: A Narrative Review.

Quarantine restrictions have changed the usual lifestyle habits of children and adolescents. In this review, we summarize how the COVID-19 outbreak changed lifestyle during childhood and discuss potential short- and long-term effects of NCD high-risk behaviors on health outcomes. literature search was conducted in Medline database (PubMed), Scopus, Embase, Web of Science, and Google Scholar.

The First Report of Iranian Registry of Patients with Spinal Muscular Atrophy.

Background: Insufficient amounts of survival motor neuron protein is leading to one of the most disabling neuromuscular diseases, spinal muscular atrophy (SMA). Before the current study, the detailed characteristics of Iranian patients with SMA had not been determined.

Objective: To describe the key demographic, clinical, and genetic characteristics of patients with SMA registered in the Iranian Registry of SMA (IRSMA).

Effect of parenting intervention through "Care for Child Development Guideline" on early child development and behaviors: a randomized controlled trial.

Background: Several studies showed that parenting intervention programs play a core component in early child development. Considering the limited healthcare resources in developing countries, group-session intervention based on care for child development (CCD) guideline might be cost-effective.

Methods: This randomized controlled trial was conducted at an outpatient public Pediatrics clinic in Isfahan, Iran.

Latent Class Analysis of knowledge, Attitude, and Practice of a Population-Based Sample of Iranian Pregnant Women toward COVID-19.

Background: The aim of the study is to identify latent class (LC)-derived patterns of women's knowledge, attitude, and practice (KAP) toward coronavirus disease 2019 (COVID-19) in Iran.

Materials And Methods: This cross-sectional survey of 2029 women, who participated in the PERSIAN Birth Cohort, was conducted in Isfahan, Iran. KAP was assessed by shortened and validated form of a recently used questionnaire in Iran.

Paroxysmal hemicrania in children and adolescents: A systematic review.

Objective: We aimed to report the accessible demographic, clinical, and radiological characteristics of reported pediatric paroxysmal hemicrania (PH).

Introduction: It has been a while since PH in a child was first described. However, it is still unknown whether children's PH follows the same patterns as adults.

Parental Occupational Exposure and Neurodevelopmental Disorders in Offspring: a Systematic Review and Meta-analysis.

Purpose Of Review: Parental occupational exposures might be associated with neurodevelopmental disorders (NDDs) in offspring. We aimed to conduct a systematic review and meta-analysis to summarize and synthesize the current literature and to estimate the pooled magnitude of the underlying association(s) between parental occupational exposures and subsequent risk of NDDs.

Recent Findings: In the meta-analysis of 20 included studies, significant associations were found between parental occupational exposure to pesticides or solvents and the risk of attention deficit hyperactivity disorder in offspring.

Knowledge, Attitudes, and Practices toward COVID-19 among Persian Birth Cohort Participants.

Background: Knowledge, attitudes, and practices (KAP) toward COVID-19 play an important role in controlling the outbreak. The present study aimed to investigate the KAP of a group of women toward COVID-19 during the second wave of the outbreak in Iran.

Method And Material: A cross-sectional survey of 2862 women was conducted in May and June 2020 in two centers of Persian birth cohort.

A meta-analysis on the effect of telemedicine on the management of attention deficit and hyperactivity disorder in children and adolescents.

Introduction: This study aims to report the effect sizes of telemedicine treatments on the symptom domains of paediatric ADHD.

Methods: In this systematic review and meta-analysis, electronic databases, i.e.

Estimation of Cardiovascular Disease Risk Factors in the Undefined Participants of Campaign in Isfahan in 2017.

Background: The cardiovascular mortality rate in Iran has been reported 65% of all death recently. Despite the high prevalence of cardiovascular diseases (CVD) risk factors and its burden in developing countries, public awareness of CVD symptoms and its risk factors are very low, leading to poor control of these risk factors.

Methods: Our study is a cross-sectional study that was conducted in an undefined sample of 163 individuals who participated in a public health campaign.

Association of serum 25-hydroxyvitamin D concentration with anthropometric measures in children and adolescents: the CASPIAN-V study.

Background: Serum 25-hydroxyvitamin D (25(OH)D) concentrations reflect vitamin D status, with deficiency implicated as an underlying factor for many adverse health effects. This study aims to analyze the association between vitamin D status and different anthropometric measures in a large pediatric population.

Methods: This nationwide cross-sectional study was conducted in 2019 in blood samples obtained from school students of 30 provinces in Iran.

Evaluation of non-motor symptoms and their impact on quality of life in patients with Parkinson's disease, Isfahan, Iran.

Parkinson's disease (PD) is diagnosed on the basis of motor symptoms, but non-motor symptoms (NMS) have high prevalence in PD and often antecede motor symptoms for years and cause severe disability. This study was conducted to determine the prevalence of NMS in patients with PD. This cross-sectional study was performed in Isfahan, Iran, on patients with PD.