Short- and long-term modulation of microvascular responses in streptozotocin-induced diabetic rats by glycosylated products.

Objective: This study aimed to determine the role of early and late glycation products in modulating inflammation in early diabetes.

Materials: Sprague-Dawley rats (130-170 g) were injected with streptozotocin (75 mg/kg, ip) and treated with daily aminoguanidine (AG, 25 mg/kg, ip) or vehicle for 2 or 4 weeks.

Methods: The base of a vacuum-induced blister raised on the hind paw was perfused with substance P (SP, 1 microM) and sodium nitroprusside (SNP, 100 microM).