Publications by authors named "Maryam Balogun"
Article Synopsis
- The study aimed to determine the effectiveness and safety of starting direct oral anticoagulants (DOACs) early versus delayed in patients with acute ischaemic stroke and atrial fibrillation.
- Conducted as a multicenter, randomized controlled trial across 100 UK hospitals, 3,648 patients were initially assigned to either early initiation (within 4 days) or delayed initiation (7-14 days) of anticoagulation.
- The primary outcome measured was the incidence of complications like recurrent stroke or bleeding within 90 days, with results being analyzed by an independent committee to ensure objectivity.
Critical periods are windows of heightened plasticity occurring during neurodevelopment. Alterations in neural activity during these periods can cause long-lasting changes in the structure, connectivity, and intrinsic excitability of neurons, which may contribute to the pathology of neurodevelopmental disorders. However, endogenous regulators of critical periods remain poorly defined.
View Article and Find Full Text PDFBackground: Many infancy-onset epilepsies have poor prognosis for seizure control and neurodevelopmental outcome. Ketogenic diets can improve seizures in children older than 2 years and adults who are unresponsive to antiseizure medicines. We aimed to establish the efficacy of a classic ketogenic diet at reducing seizure frequency compared with further antiseizure medicine in infants with drug-resistant epilepsy.
View Article and Find Full Text PDFArticle Synopsis
- Atrial fibrillation is linked to a significant percentage of ischemic strokes, prompting the need for effective early anticoagulation to reduce the risk of stroke recurrence.
- The OPTIMAS study tests if starting direct oral anticoagulants within four days post-stroke is more effective than delaying treatment for 7-14 days.
- The research will assess outcomes like recurrent stroke and major bleeding, involving nearly 3,500 participants across UK centers to evaluate the safety and effectiveness of early anticoagulation.