Non-spike protein inhibition of SARS-CoV-2 by natural products through the key mediator protein ORF8.

The recent pernicious COVID-19 pandemic is caused by SARS-CoV-2. While most therapeutic strategies have focused on the viral spike protein, Open Reading Frame 8 (ORF8) plays a critical role in causing the severity of the disease. Nonetheless, there still needs to be more information on the ORF8 binding epitopes and their appropriate safe inhibitors.

In-silico structural analysis of amyloid beta: an anti-Alzheimer's peptide.

, known as the Naked mole-rat, has an extraordinary immunity to Alzheimer's disease. The pathological hallmark of Alzheimer's disease is cerebral accumulations of plaques, consisting of self-aggregated amyloid beta peptides. and amyloid beta peptides are different in only one amino acid.

Structural arrangement of the active back-to-back dimer in N-glycosylated ErbB receptors is regulated by heterodimerization.

The human epidermal growth factor receptor (EGFR/ErbB) family consists of four members (ErbB1-4) and belongs to the superfamily of receptor tyrosine kinases (RTKs). The ErbB family members participate in multiple cellular pathways and are the key players in several cancers (brain, breast, lung etc.).

Enhanced photocatalytic water splitting of a SILAR deposited α-FeO film on TiO nanoparticles.

We have investigated the effect of deposition of a α-FeO thin layer on a substrate of TiO nanoparticles for photoelectrochemical (PEC) water splitting. The TiO layer was coated on an FTO substrate using the paste of TiO nanoparticles. The α-FeO layer was deposited on the TiO thin film, using the method of Successive Ionic Layer Adsorption and Reaction (SILAR) with different cycles.

Highly efficient hydroxyapatite/TiO2 composites covered by silver halides as E. coli disinfectant under visible light and dark media.

TiO2-based photocatalysts are seen as the most common agents for the photodegradation of bacteria. In this study, AgCl/TiO2, hydroxyapatite(Hp)/AgCl/TiO2, AgI/TiO2, and Hp/AgI/TiO2 were prepared by the deposition-precipitation method on P25 TiO2 nanoparticles and were characterized by XRD, SEM, FT-IR, EDX and BET methods. The prepared composites showed high efficiency for the inactivation of Escherichia coli (E.