A point of care sensor for detection of alcohols, aldehydes and esters in urinary metabolites of war veterans injured by sulfur mustard.

To discriminate between different alcoholic, aldehyde, and ester species of urine samples, a colorimetric sensor array consisting of dopamine-capped copper-silver bimetallic nanoparticles (Ag@Cu BMNPs) combined with 12 organic dyes is introduced. Based on the sensing mechanism, the nanozyme catalyzed the reactions of oxidation, dehydrogenation, and hydrolysis of volatile organic compounds. The products could alter the amount of hydronium ions in the detection media, making a variation in the color intensity of pH-sensitive indicators.

Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats.

The marine environment with its vast biological diversity encompasses many organisms that produce bioactive natural products. Marine microorganisms are rich sources of compounds from many structural classes with a multitude of biological activities. The biosynthesis of microbial natural products depends on a variety of biotic and abiotic factors in the marine environment, including temperature, nutrients, salinity and interaction with other microorganisms.

Synthesis and biological evaluation of some novel diastereoselective benzothiazole β-lactam conjugates.

Highly diastereoselective synthesis of some novel benzothiazole-substituted β-lactam hybrids was achieved starting from (benzo[d]thiazol-2-yl)phenol as an available precursor. This is the first time (benzo[d]thiazol-2-yl)phenoxyacetic acid has been used as ketene source in synthesizing monocyclic 2-azetidinones. These compounds were evaluated for their antimicrobial activities against a large panel of Gram-positive and Gram-negative bacterial strains and moderate activities were encountered.