Publications by authors named "Maryam Al Mansi"
Article Synopsis
- The study investigates how prenatal exposure to endocrine disrupting chemicals (EDCs), specifically bisphenol A (BPA) and diethylhexyl phthalate (DEHP), affects the behavior of male and female rats.
- Results show that female offspring exhibited reduced anxiety in certain behavioral tests, while males showed signs of feminization and maladaptive defensive behaviors, particularly with higher doses of DEHP.
- The findings indicate that exposure to EDCs during pregnancy leads to sex-specific behavioral changes, altered corticosterone levels, and changes in adrenal gland weights, with varying effects based on dosage and chemical combinations.
The objective of this study was to evaluate the effects of gestational exposure to low doses of bisphenol A (BPA), bisphenol S (BPS), and bisphenol F (BPF) on pregnancy outcomes and offspring development. Pregnant Sprague-Dawley rats were orally dosed with vehicle, 5 μg/kg body weight (BW)/day of BPA, BPS and BPF, or 1 μg/kg BW/day of BPF on gestational days 6-21. Pregnancy and gestational outcomes, including number of abortions and stillbirths, were monitored.
View Article and Find Full Text PDFBisphenol A (BPA) and Diethylhexyl Phthalate (DEHP) are well-studied endocrine disrupting chemicals (EDCs), however, the effects of mixtures of these EDCs are not. To assess the consequences of prenatal exposure to a mixture of these EDCs, dams were orally administered either saline (control), BPA (5 μg/kg BW/day), high dose DEHP (HD-D; 7.5 mg/kg BW/day), or a combination of BPA with HD-D in experiment 1; saline, BPA (5 μg/kg BW/day), low-dose DEHP (LD-D; 5 μg/kg BW/day) or a combination of BPA with LD-D in experiment 2.
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