Dual-mode optical biocompatible-sensor enabled by enzyme-like activity of UiO-66 (Zr) for ultra-sensitive ROS detection in vitro.

The simple, effective and highly sensitive detection of hydrogen peroxide (HO), which belongs to the reactive oxygen species (ROS), at low concentrations plays an indispensable role in the field of environmental protection, biological research and safety. In this study, a dual-mode optical biosensor, UiO-66@OPD, was developed based on the inherent peroxidase mimicking activity of UiO-66 (Zr) and the optical reaction of ortho-phenylenediamine (OPD) by extending the π-system through oxidative coupling, prototropism and elimination to form OPDox, thereby exhibiting strong orangish absorbance and greenish fluorescence. The catalase-mimicking activity of UiO-66 (Zr) was demonstrated by the catalytic oxidation of methylene blue in the presence of HO.

Association of Demographic, Clinical, and Vaccination Characteristics with COVID-19 Viral Load Assessed by qRT-PCR.

Background: The effect of vaccination on the SARS-CoV-2 baseline viral load and clearance during COVID-19 infection is debatable. This study aimed to assess the effects of demographic and vaccination characteristics on the viral load of SARS-CoV-2.

Methods: We included the patients referred for outpatient SARS-CoV-2 qRT-PCR (reverse transcriptase quantitative polymerase chain reaction) test between July and September 2022.

Design and synthesis of molecularly imprinted polypyrrole based on nanoreactor SBA-15 for recognition of ascorbic acid.

Molecular imprinting is an attractive technique for preparing mimics of natural and biological receptors. Nevertheless, molecular imprinting for aqueous systems remains a challenge due to the hydrogen bonding between templates and functional monomers destroyed in the bulk water. The hydrogen bonding between templates and monomers are the most crucial factor governing recognition, particularly in non-covalent molecularly imprinted polymers.

Selective adsorption of 2,4-dinitrophenol on molecularly imprinted nanocomposites of mesoporous silica SBA-15/polyaniline.

Surface imprinting and adoption of a nano-sized physical form are two effective approaches to overcome the template transfer difficulty within molecularly imprinted polymers (MIPs). This work is an attempt to conquer the problem of template transfer difficulty within MIPs by using a nano-reactor as a substrate for the reaction between the monomer and the template. Negatively charged hexagonal nano-channels of SBA-15 can act as a support for attachment of positively charged aniline monomers and the 2,4-dinitrophenol (2,4-DNP) template.