Community detection in empirical kinase networks identifies new potential members of signalling pathways.

Phosphoproteomics allows one to measure the activity of kinases that drive the fluxes of signal transduction pathways involved in biological processes such as immune function, senescence and cell growth. However, deriving knowledge of signalling network circuitry from these data is challenging due to a scarcity of phosphorylation sites that define kinase-kinase relationships. To address this issue, we previously identified around 6,000 phosphorylation sites as markers of kinase-kinase relationships (that may be conceptualised as network edges), from which empirical cell-model-specific weighted kinase networks may be reconstructed.

DUKweb, diachronic word representations from the UK Web Archive corpus.

Lexical semantic change (detecting shifts in the meaning and usage of words) is an important task for social and cultural studies as well as for Natural Language Processing applications. Diachronic word embeddings (time-sensitive vector representations of words that preserve their meaning) have become the standard resource for this task. However, given the significant computational resources needed for their generation, very few resources exist that make diachronic word embeddings available to the scientific community.

Core-periphery structure in directed networks.

Empirical networks often exhibit different meso-scale structures, such as community and core-periphery structures. Core-periphery structure typically consists of a well-connected core and a periphery that is well connected to the core but sparsely connected internally. Most core-periphery studies focus on undirected networks.