Publications by authors named "MaryLynn FitzSimons"
The inability to effectively stimulate cardiomyocyte proliferation remains a principle barrier to regeneration in the adult human heart. A tightly regulated, acute inflammatory response mediated by a range of cell types is required to initiate regenerative processes. Prostaglandin E (PGE), a potent lipid signaling molecule induced by inflammation, has been shown to promote regeneration and cell proliferation; however, the dynamics of PGE signaling in the context of heart regeneration remain underexplored.
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- Endoglin is a crucial protein involved in blood vessel formation (angiogenesis) and, when mutated, leads to a genetic condition called hereditary hemorrhagic telangiectasia (HHT), which causes vascular issues in humans.
- The study demonstrates that endoglin influences the position of another protein, zyxin, in focal adhesions, which are cell structures that help cells stick to their surroundings, particularly in response to BMP9 signals.
- The findings reveal a connection between endoglin and the Hippo signaling pathway, particularly involving YAP1, suggesting that mutations affecting endoglin can disrupt cellular responses and contribute to related vascular diseases by altering cell behavior and inflammatory responses.