Publications by authors named "MaryAnn Matzinger"
Purpose: Prevention of fractures is an unmet need in glucocorticoid (GC)-treated Duchenne muscular dystrophy. This study explored factors associated with incident vertebral fractures (VFs) to inform future fracture prevention efforts.
Methods: VFs were evaluated prospectively at study baseline and 12 months on lateral spine radiographs in participants aged 4 to 25 years with Duchenne muscular dystrophy.
Article Synopsis
- The study focuses on the high prevalence of vertebral fractures (VF) in boys and young men with Duchenne muscular dystrophy (DMD) due to muscle weakness and osteoporosis caused by steroid treatment.
- Researchers analyzed clinical factors in 60 participants aged 4-25, finding that those with VF were generally shorter and had longer exposure to glucocorticoids, along with greater bone age delay and lower lumbar spine bone mineral density.
- Results showed that every 0.1 mg/kg/day increase in glucocorticoid dosage significantly raised the risk of spinal deformities, indicating a direct link between steroid treatment and bone fragility in DMD patients.
Although bone fragility may already be present at diagnosis of pediatric acute lymphoblastic leukemia (ALL), routine performance of dual-energy X-ray absorptiometry (DXA) in every child is not universally feasible. The aim of this study was to develop and validate a risk prediction model for low lumbar spine bone mineral density (LS BMD Z-score ≤ -2.0) at diagnosis, as an important indicator for fracture risk and further treatment-related BMD aggravation.
View Article and Find Full Text PDFObjectives: Our objectives were to assess the magnitude of the disparity in lumbar spine bone mineral density (LSBMD) Z-scores generated by different reference databases and to evaluate whether the relationship between LSBMD Z-scores and vertebral fractures (VF) varies by choice of database.
Patients And Design: Children with leukemia underwent LSBMD by cross-calibrated dual-energy x-ray absorptiometry, with Z-scores generated according to Hologic and Lunar databases. VF were assessed by the Genant method on spine radiographs.
Purpose: Vertebral fractures due to osteoporosis are a potential complication of childhood acute lymphoblastic leukemia (ALL). To date, the incidence of vertebral fractures during ALL treatment has not been reported.
Patient And Methods: We prospectively evaluated 155 children with ALL during the first 12 months of leukemia therapy.
Objective: To determine the frequency of incident vertebral fractures (IVF) 12 months after glucocorticoid (GC) initiation in children with rheumatic diseases and to identify children at higher risk.
Methods: Children with rheumatic diseases initiating GC were enrolled in a prospective observational study. Annual spine radiographs were evaluated using the Genant semiquantitative method.
Glucocorticoids (GCs) are associated with fragility fractures in children with various chronic illnesses. The impact of GCs on bone health in children with nephrotic syndrome (NS) is less well understood. Here we report skeletal findings in a 10-year-old boy with steroid-sensitive NS who presented with back pain due to vertebral fractures 5 years after NS diagnosis.
View Article and Find Full Text PDFAdvanced vertebral fracture among newly diagnosed children with acute lymphoblastic leukemia: results of the Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) research program.
J Bone Miner Res
July 2009
Article Synopsis
- Vertebral compression fractures are a serious issue in children diagnosed with acute lymphoblastic leukemia (ALL), with 16% of a studied group showing signs of these fractures within 30 days of diagnosis.
- A study involving 186 children revealed that most fractures occurred in the thoracic spine, and that lower bone mineral density (BMD) was associated with a higher likelihood of fractures.
- The results emphasize that vertebral compression fractures are often overlooked in new ALL diagnoses, and further research is needed to see if these fractures heal during or after treatment.
Article Synopsis
- Children with cerebral palsy from periventricular leukomalacia often experience unprovoked seizures, with a study showing that 26% of the analyzed group had epilepsy.
- Significant risk factors for epilepsy included different types of cerebral palsy, mental disabilities, visual impairments, and history of neonatal seizures, with neonatal seizures being a particularly strong predictor.
- This research is unique as it specifically links neonatal seizures to later epilepsy in children with this specific cerebral pathology, contributing to the understanding of epilepsy risk in these patients.
The purpose of this study was to examine cognitive functioning and neuroimaging in children with leukemia treated with the Pediatric Oncology Group 9605 protocol at the Children's Hospital of Eastern Ontario. Mean age at diagnosis was 4.88 +/- 2.
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