Comparative pharmacokinetics of phenylbutazone in healthy young-adult and geriatric horses.

Objective: To evaluate the effects of aging on phenylbutazone (PBZ) disposition in older horses (≥ 25 years old) compared to young adults (4 to 10 years old) by characterizing the pharmacokinetic profile of PBZ and its active metabolite, oxyphenbutazone (OPBZ), following a 2.2-mg/kg dose, IV. We hypothesized that the disposition of PBZ will be affected by age.

Assessment of the impact of age and of blood-derived inflammatory markers in horses with colitis.

Objectives: To determine the impact of age on survival in horses with colitis and to elucidate whether a lower type-1/type-2 cytokine ratio or an exaggerated inflammatory state contribute to reduced survival in aged horses.

Design: Part 1: Retrospective cohort analysis. Part 2: Analytic observational study.

Comparative evaluation of clinical findings and prognostic outcome parameters in hospitalized, critically ill neonatal foals and crias.

Objective: Species-related differences in the prevalence, manifestation, and outcome of neonatal illness may impact management practices of neonatal intensive care. The study aimed to elucidate similarities between disease manifestations and mortality risks of critically ill (CI) neonatal crias and foals admitted to the same referral center.

Design: A comparative, retrospective cohort evaluation of two species (camelid and equine).

Assessment of clinical and microbiota responses to fecal microbial transplantation in adult horses with diarrhea.

Background And Aims: Fecal microbial transplantation (FMT) is empirically implemented in horses with colitis to facilitate resolution of diarrhea. The purpose of this study was to assess FMT as a clinical treatment and modulator of fecal microbiota in hospitalized horses with colitis.

Methods: A total of 22 horses with moderate to severe diarrhea, consistent with a diagnosis of colitis, were enrolled at two referral hospitals (L1: n = 12; L2: n = 10).

The fecal microbiota of healthy donor horses and geriatric recipients undergoing fecal microbial transplantation for the treatment of diarrhea.

Background And Aims: Fecal microbial transplantation (FMT), a treatment for certain gastrointestinal conditions associated with dysbiosis in people, is also empirically employed in horses with colitis. This study used microbiota high-throughput sequencing to compare the fecal microbial profile of healthy horses to that of geriatric microbial transplant recipients experiencing diarrhea and tested whether FMT restores microbiota diversity.

Methods: To evaluate the effect of environment and donor characteristics on the intestinal microbiota, fecal samples were collected per rectum from 15 healthy young-adult (2-12 years) and 15 geriatric (≥20 years) horses.

Survey of human-horse relationships and veterinary care for geriatric horses.

OBJECTIVE To assess relationships between horse owners (or lessees) and geriatric or nongeriatric horses and to investigate factors influencing veterinary care decision-making. DESIGN Descriptive, cross-sectional, survey-based study. SAMPLE 2,879 people who owned or leased ≥ 1 horse.

Use of a multivariable model to estimate the probability of discharge in hospitalized foals that are 7 days of age or less.

Objective: To create a mathematical model to assist in early prediction of the probability of discharge in hospitalized foals < or= 7 days old.

Study Design: Prospective study.

Animals: 1,073 foals.

Bacterial meningitis and brain abscesses secondary to infectious disease processes involving the head in horses: seven cases (1980-2001).

Objective: To determine clinical features of horses with bacterial meningitis or brain abscesses secondary to infectious disease processes involving the head.

Design: Retrospective study.

Animals: 7 adult horses.

Assessment of clinical characteristics, management practices, and activities of geriatric horses.

Objective: To describe the demographic and clinical characteristics, management practices, and owner perception of a population of geriatric horses, and to compare these data with findings in a group of younger horses.

Design: Original study.

Animals: 218 horses.

Demographic and clinical characteristics of geriatric horses: 467 cases (1989-1999).

Objective: To describe the demographic and clinical characteristics of a population of geriatric horses.

Design: Retrospective study.

Animals: 467 horses that were > or = 20 years of age.

Demographics of health and disease in the geriatric horse.

Owners of older horses have generally owned them for a long time. They have developed a bond that is similar to that seen with companion animals. Their desire to have their animal(s) age gracefully with comfort and mobility has stirred research in the field of equine geriatric medicine.