Publications by authors named "Mary-Louise Manchadi"
Despite progress made with immune checkpoint inhibitors and targeted therapies, skin cancer remains a significant public health concern in the United States. The intricacies of the disease, encompassing genetics, immune responses, and external factors, call for a comprehensive approach. Techniques in systems genetics, including transcriptional correlation analysis, functional pathway enrichment analysis, and protein-protein interaction network analysis, prove valuable in deciphering intricate molecular mechanisms and identifying potential diagnostic and therapeutic targets for skin cancer.
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- This study focuses on the under-researched area of lizard venoms, specifically their structural and functional diversity among anguimorph lizards.
- Researchers found significant variability in venom composition across 20 different lizard species, highlighting the multifunctional role of kallikrein enzymes and other toxins.
- The findings suggest that lizard venoms are influenced by different selection pressures in their families, presenting a potential for discovering new bioactive molecules useful for drug development.