Clinical trial of wellness training: health promotion for severely mentally ill adults.

This randomized controlled trial examined benefits of adding active health promotion to basic primary care (BPC) services for SMI adults. It compared BPC with BPC plus wellness training (WT), a 12 months intervention promoting individual skills in self-management. Three hundred nine participants enrolled during short-term residential treatment completed baseline assessments and were assigned to treatment groups, before discharge.

Temperature excursions at the pulp-dentin junction during the curing of light-activated dental restorations.

Objectives: Excessive heat produced during the curing of light-activated dental restorations may injure the dental pulp. The maximum temperature excursion at the pulp-dentin junction provides a means to assess the risk of thermal injury. In this investigation we develop and evaluate a model to simulate temperature increases during light-curing of dental restorations and use it to investigate the influence of several factors on the maximum temperature excursion along the pulp-dentin junction.

Recidivism in HIV-infected incarcerated adults: influence of the lack of a high school education.

Recidivism is a pervasive problem facing the incarcerated. Incarcerated persons who are human immunodeficiency virus (HIV)-infected often have multiple risk factors associated with initial incarceration and recidivism, in particular, injection drug use. Yet, some jails provide case management for HIV-infected inmates to provide continuity of health care, which might have positive effects on reentry into the community.

Discharge planning and continuity of health care: findings from the San Francisco County Jail.

Continuity of health care among the formerly incarcerated is an emerging public health challenge. We used data from the San Francisco County Jail to determine whether discharge planning improves access to care on release. Inmates who were HIV positive and received discharge planning were 6 times more likely to have a regular source of care in the community compared with inmates with other chronic medical conditions, and they were as likely to have a regular source of care compared with the general San Francisco population.

Health and health behaviors in HIV-infected jail inmates, 1999 and 2005.

Incarcerated HIV-infected persons in San Francisco have benefited from intensive case management in jail and postrelease, which includes but is not focused on interventions to prevent transmission. In this population of predominately injection drug users (IDUs), we had the opportunity to examine interview data from 1999 and 2005 that included health characteristics and risk factors. Those in 2005 were less likely to be satisfied with social support and less likely to be partnered; more likely to have some form of health insurance.

The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression.

Objective: The development and progression of severe sepsis is related to a deficiency in pro-inflammatory cytokine production, characterised by lesser IFNgamma levels, which are not explained by variations in levels of the main putative regulator of IFNgamma, namely IL-12. As alternative regulators of IFNgamma may be of greater importance in human sepsis, we investigated the hypothesis that the development of severe sepsis is related to variations in IL-18, IL-23 and IL-27 gene expression.

Design And Setting: A prospective observational trial in a mixed intensive care unit (ICU) and hospital wards in a university teaching hospital.

Beliefs, risk perceptions, and gaps in knowledge as barriers to colorectal cancer screening in older adults.

Objectives: To assess beliefs and perceptions of risk about colorectal cancer (CRC) and gaps in knowledge about screening in adults aged 65 to 89.

Design: A population-based survey.

Setting: United States.

Basic skills for working with smokers: a pilot test of an online course for medical students.

Background: Online learning can be an excellent method for presenting clinical skills to address health behaviors.

Methods: Medical students pilot tested a skills-building course consisting of an online component and a practical application.

Results: A total of 38 students were registered, 25 (66%) completed the online component, and 22 (58%) completed both course components.

A right to benefit from international research: a new approach to capacity building in less-developed countries.

This article proposes a means by which benefits provided in international research collaborations might be employed to strengthen health care, research, and other capacities in less-developed countries. The Declaration of Helsinki and CIOMS Guidelines define certain expectations of benefits, but these requirements are ambiguous, logistically problematic, and studies suggest they are inconsistently upheld. Drawing on the principle of respect for persons, a right to benefit from hosting externally-sponsored research is proposed.

Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses.

Background: Hereditary Hemochromatosis (HH) is a genetic disease associated with iron overload, in which individuals homozygous for the mutant C282Y HFE associated allele are at risk for the development of a range of disorders particularly liver disease. Conformational diseases are a class of disorders associated with the expression of misfolded protein. HFE C282Y is a mutant protein that does not fold correctly and consequently is retained in the Endoplasmic Reticulum (ER).

Using tailored telephone counseling to accelerate the adoption of colorectal cancer screening.

Background: Few interventions to increase colorectal cancer screening have used a stage of change model to promote screening adoption. None have used computer-assisted tailored telephone counseling calls. This study's purpose was to implement and evaluate stage-based computer-assisted tailored telephone counseling to promote colorectal cancer screening in a primary care population.

Inferring developmental constraint and constraint release: primordial germ cell determination mechanisms as examples.

Developmental constraint and its converse constraint release are significant concepts in understanding pattern and process in macroevolution. The purpose of this paper is to propose a two-step method for identifying constraints and constraint release. The first step is a phylogenetic optimization procedure to identify which trait/process is primitive and which is derived.

Depression and quality of life in women after a myocardial infarction.

Background: Cardiovascular disease is the number one cause of mortality and morbidity among women in the United States, resulting in 25,000 deaths annually. Despite this high mortality figure, most women survive. Although evidence suggests that depression is common after myocardial infarction (MI), there are limited data on how depression impacts women's recovery after their first event.

The occurrence of severe sepsis and septic shock are related to distinct patterns of cytokine gene expression.

Patient response to acute bacterial infection is highly variable. Differing outcomes in this setting may be related to variations in the immune response to an infectious insult. Using quantitative real-time polymerase chain reaction, we quantified gene expression of the tumor necrosis factor alpha(TNFalpha), interferon gamma (IFNgamma), and interleukin 10 (IL10), IL12p35, and IL4 genes in 3 patient groups.

Diabetes care in the San Francisco County Jail.

Chronic disease management is becoming increasingly important in correctional settings, especially diabetes. We conducted a retrospective chart review of diabetic inmates in San Francisco County Jail and examined the sociodemographic characteristics, markers of disease status, and compliance with jail-specific care guidelines within this setting. We found high rates of compliance with immediate-term care guidelines (e.

Evaluation of serum immunoglobulins among individuals living near six Superfund sites.

Residents living in communities near Superfund sites have expressed concern that releases from these facilities affect their health, including adverse effects on their immune systems. We used data from six cross-sectional studies to evaluate whether people who live near several Superfund sites are more likely to have individual immunoglobulin test results (IgA, IgG, and IgM) below or above the reference range than those who live in comparison areas with no Superfund site. Study participants consisted of target-area residents who lived close to a Superfund site and comparison-area residents who were not located near any Superfund or hazardous waste sites.

Evaluating the use of an online gaming community in a pediatric hemodialysis center.

Children that suffer from chronic illnesses are at risk of developing behavioral disorders stemming from a lack of self esteem,frequent removal from their peer support networks, and feeling a sense of injustice with regards to their medical condition and the health of their peers.Furthermore, the process of hemodialysis can be a socially isolating experience by way of being tied to a machine that restricts freedom of movement and social activity amongst concomitant users.

History of arrest, incarceration and victimization in community-based severely mentally ill.

This study examined history of arrest and victimization in an urban community sample of severely mentally ill adults. Adults (n = 308) were consented and interviewed in one of four short-term residential treatment facilities in San Francisco. Nearly three quarters (71.

Predictors of physical functioning among adults with severe mental illness.

Objectives: Living conditions and treatment-related factors contribute to high rates of comorbid medical illness among adults with severe mental illness and undermine their physical well-being. This study examined physical functioning scores for this population and compared them with national norms.

Methods: A total of 309 residential care clients completed interviews.