A tumor-restricted glycoform of podocalyxin is a highly selective marker of immunologically cold high-grade serous ovarian carcinoma.

Introduction: Targeted-immunotherapies such as antibody-drug conjugates (ADC), chimeric antigen receptor (CAR) T cells or bispecific T-cell engagers (eg, BiTE) all aim to improve cancer treatment by directly targeting cancer cells while sparing healthy tissues. Success of these therapies requires tumor antigens that are abundantly expressed and, ideally, tumor specific. The CD34-related stem cell sialomucin, podocalyxin (PODXL), is a promising target as it is overexpressed on a variety of tumor types and its expression is consistently linked to poor prognosis.

Spatially Resolved Tumor Microenvironment Predicts Treatment Outcomes in Relapsed/Refractory Hodgkin Lymphoma.

Purpose: About a third of patients with relapsed or refractory classic Hodgkin lymphoma (r/r CHL) succumb to their disease after high-dose chemotherapy followed by autologous stem-cell transplantation (HDC/ASCT). Here, we aimed to describe spatially resolved tumor microenvironment (TME) ecosystems to establish novel biomarkers associated with treatment failure in r/r CHL.

Patients And Methods: We performed imaging mass cytometry (IMC) on 71 paired primary diagnostic and relapse biopsies using a marker panel specific to CHL biology.

Long-term neurological dysfunction associated with COVID-19: Lessons from influenza and inflammatory diseases?

As the COVID-19 pandemic persists, SARS-CoV-2 infection is increasingly associated with long-term neurological side effects including cognitive impairment, fatigue, depression, and anxiety, colloquially known as "long-COVID." While the full extent of long-COVID neuropathology across years or even decades is not yet known, we can perhaps take direction from long-standing research into other respiratory diseases, such as influenza, that can present with similar long-term neurological consequences. In this review, we highlight commonalities in the neurological impacts of influenza and COVID-19.

Comparative sequence analysis elucidates the evolutionary patterns of in New Mexico over thirty-two years.

Background: , a Gram-negative bacterium, is the causative agent of plague. is a zoonotic pathogen that occasionally infects humans and became endemic in the western United States after spreading from California in 1899.

Methods: To better understand evolutionary patterns in from the southwestern United States, we sequenced and analyzed 22 novel genomes from New Mexico.

Short- and Long-Term Outcomes of Hematologic Malignancy Patients After Cardiopulmonary Resuscitation: Experience of a Large Oncology Center.

Purpose: The objective of this study is to describe characteristics and short- and long-term outcomes of patients with hematologic malignancies who received cardiopulmonary resuscitation (CPR).

Methods: A retrospective review was conducted of all Code Blues at a large comprehensive cancer center. Demographic, clinical, and outcome variables were analyzed for patients with a hematologic malignancy who underwent CPR.

Survey of Nurses' Experiences Applying The Joint Commission's Medication Management Titration Standards.

Background: Critical care nurses titrate continuous infusions of medications to achieve clinical end points. In 2017, The Joint Commission (TJC) placed restrictions on titration practice, decreasing nurses' autonomous decision-making.

Objectives: To describe the practice and perceptions of nurses regarding the 2017 TJC accreditation/regulatory standards for titration of continuous medication infusions.

Chlamydia Infection Among Adolescent Long-Acting Reversible Contraceptive and Shorter-Acting Hormonal Contraceptive Users Receiving Services at New York City School-Based Health Centers.

Study Objective: One concern regarding long-acting reversible contraceptive (LARC) use among female adolescents is the potential for sexually transmitted infection acquisition. Few studies investigate chlamydia infection among adolescent LARC users compared with other hormonal contraceptive method (non-LARC) users. We hypothesized that incident chlamydia infection would be similar in these 2 groups and that it would not be associated with adolescent LARC use.

Revised Self-Report Assessment of Functional Visual Performance (R-SRAFVP)-Part II: Construct Validation.

Objective: Our objective was to validate the construct of the Revised Self-Report Assessment of Functional Visual Performance (R-SRAFVP) for older adults with low vision resulting from age-related eye disease.

Method: The 50-item draft of the R-SRAFVP was administered to 87 older adults with low vision. Construct validation included principal-components analysis and the known-groups method.

Revised Self-Report Assessment of Functional Visual Performance (R-SRAFVP)-Part I: Content Validation.

Objective: We describe the development and content validation of the revised Self-Report Assessment of Functional Visual Performance (R-SRAFVP).

Method: The content validation process consisted of three stages: (1) three occupational therapy experts in low vision rehabilitation revised items on the 38-item SRAFVP via written feedback and semistructured interview, (2) eight occupational therapy low vision experts evaluated items for relevance and provided feedback on the rating scale, and (3) five adults with low vision provided feedback on item clarity via cognitive interviewing.

Results: In Stage 1 review, 21 items were added, totaling 59 items.

Health Literacy in Older Adults With and Without Low Vision.

Objective: In this study, we investigated whether older adults with low vision (LV) from age-related macular degeneration (AMD) demonstrated lower functional health literacy than older adults without LV.

Method: Fifty adults with AMD were matched with adults without LV on age, gender, education, and income. We measured visual acuity, contrast sensitivity, and reading speed and administered the Test of Functional Health Literacy in Adults (TOFHLA) using two test time conditions, standard and unlimited, to measure health literacy levels.

Validation of a Reading Assessment for Persons With Homonymous Hemianopia or Quadrantanopia.

Objective: To preliminarily validate the Visual Skills for Reading Test (VSRT) for assessing reading performance in persons with homonymous hemianopia (HH) or quadrantanopia.

Design: Retrospective chart review.

Setting: University-based outpatient low vision rehabilitation center.

Prevalence of pediatric epilepsy in low-income rural Midwestern counties.

Epilepsy is one of the most common disabling neurological disorders, but significant gaps exist in our knowledge about childhood epilepsy in rural populations. The present study assessed the prevalence of pediatric epilepsy in nine low-income rural counties in the Midwestern United States overall and by gender, age, etiology, seizure type, and syndrome. Multiple sources of case identification were used, including medical records, schools, community agencies, and family interviews.

Client and therapist perspectives on the influence of low vision and chronic conditions on performance and occupational therapy intervention.

Objective: We explored how vision loss and comorbid chronic conditions influence occupational therapy intervention by gathering perspectives from occupational therapists treating clients with low vision and from older adults with low vision.

Method: We surveyed 59 occupational therapists on the frequency of comorbidities in their clients and their influence on low vision intervention. Eight older adults with low vision participated in in-depth interviews and observations on the influence of low vision and comorbidities on their occupational performance.

Visual concerns that interfere with daily activities in patients on rehabilitation units: a descriptive study.

The purpose of this study was to estimate the prevalence of patients with visual concerns that interfere with their activities of daily living (ADL) performance in physical rehabilitation units through occupational therapy assessment. Over the two-month study period, 215 adult inpatients from a physical rehabilitation hospital were evaluated using the Brief Vision Screen (BVS) through ADL. The BVS assessed four areas of visual concerns, namely left visual field, focusing, and near- and low-contrast acuity, while patients engaged in ADL.

Assessment of the visual status of older adults on an orthopedic unit.

PURPOSE. To examine the visual status of a cohort of older adults on an orthopedic unit to determine their level of available vision to complete everyday activities in the hospital setting. METHOD.

Exploring the impact of a pre-service interprofessional educational intervention for school mental health trainees.

With collaborative interprofessional teams integral to school mental health (SMH) service delivery, pre-service educational strategies are needed to promote interprofessional collaboration among SMH trainees. The current study evaluated the effectiveness, feasibility, and acceptability of a pre-service, interprofessional SMH educational intervention focused on promoting the cross-disciplinary competencies essential for SMH practice. Eight SMH trainees participated in the study.

Clinical application of low vision rehabilitation strategies after completion of a computer-based training module.

This study evaluated changes in occupational therapists' practice behaviors after completion of an online continuing education (CE) program delivered over a hospital Intranet system. The setting was a large rural medical system covering parts of two southeastern states. A convenience sample of 28 occupational therapists and occupational therapy assistants was recruited from the facility therapy staff.

Factors associated with comfort level of occupational therapy practitioners in providing low vision services.

OBJECTIVE. We describe the perceived adequacy of educational preparation for and comfort level of occupational therapy practitioners in providing services to clients with low vision and identify factors associated with the practitioners' comfort level. METHOD.

Reduced insulin sensitivity in adults with pseudohypoparathyroidism type 1a.

Context: Disruption of the Gsα maternal allele leads to severe obesity and insulin resistance in mice and early-onset obesity in patients with pseudohypoparathyroidism (PHP) type 1a. However, insulin resistance and glucose metabolism have not been systematically characterized in patients with PHP1a.

Objective, Design, And Setting: In a cross-sectional, case-control study, we examined insulin sensitivity, β-cell function, energy expenditure (EE), and sympathetic nervous system activity in adults with PHP1a.

Generating clinical outputs for self-reports of visual functioning.

Purpose: Visual functioning questionnaires (VFQs) address patient-centered and evidenced-based practice. The purpose of this study was to investigate the psychometrics of the Self-Report Assessment of Functional Vision Performance (SRAFVP) and present Rasch-generated patient-level outputs.

Methods: One hundred two patients were administered the 39-item SRAFVP that includes questions under the categories of reading, writing, money management, telephone usage, reading a timepiece, personal care, clothing care, meal preparation, leisure, and functional mobility.

Survey of the low vision rehabilitation curricula in occupational therapy and occupational therapy assistant programs.

Objective: We examined the preclinical curricular content pertaining to low vision rehabilitation (LVR) included in occupational therapy (OT) and occupational therapy assistant (OTA) programs.

Method: An e-mail survey containing questions about program structure and the extent of course material related to LVR in the curriculum was sent to directors of all accredited OT and OTA programs in the United States.

Results: One hundred nineteen programs responded.

Preliminary validation of a vision-dependent activities of daily living instrument on adults with homonymous hemianopia.

Objective: This study sought to validate the use of the Self-Report Assessment of Functional Visual Performance (SRAFVP) as a measure of the severity of activity of daily living (ADL) limitations in people with homonymous hemianopia (HH).

Method: Thirty adults with HH from stroke rated their level of difficulty in completing the SRAFVP.

Results: The Cronbach's αs of the SRAFVP and its three subscales (Reading, Eye-Hand Coordination, and Functional Mobility) ranged from .