A Candida auris Outbreak and Its Control in an Intensive Care Setting.

Background: Candida auris is an emerging and multidrug-resistant pathogen. Here we report the epidemiology of a hospital outbreak of C. auris colonization and infection.

Reengineering Biomedical Translational Research with Engineering Ethics.

It is widely accepted that translational research practitioners need to acquire special skills and knowledge that will enable them to anticipate, analyze, and manage a range of ethical issues. While there is a small but growing literature that addresses the ethics of translational research, there is a dearth of scholarship regarding how this might apply to engineers. In this paper we examine engineers as key translators and argue that they are well positioned to ask transformative ethical questions.

Computerizing natural history collections.

Computers are ubiquitous in the life sciences and are associated with many of the practical and conceptual changes that characterize biology's twentieth-century transformation. Yet comparatively little has been written about how scientists use computers. Despite this relative lack of scholarly attention, the claim that computers revolutionized the life sciences by making the impossible possible is widespread, and relatively unchallenged.

Using Student Engagement to Relocate Ethics to the Core of the Engineering Curriculum.

One of the core problems with engineering ethics education is perceptual. Although ethics is meant to be a central component of today's engineering curriculum, it is often perceived as a marginal requirement that must be fulfilled. In addition, there is a mismatch between faculty and student perceptions of ethics.

Taking emotion seriously: meeting students where they are.

Emotions are often portrayed as subjective judgments that pose a threat to rationality and morality, but there is a growing literature across many disciplines that emphasizes the centrality of emotion to moral reasoning. For engineers, however, being rational usually means sequestering emotions that might bias analyses-good reasoning is tied to quantitative data, math, and science. This paper brings a new pedagogical perspective that strengthens the case for incorporating emotions into engineering ethics.

Modernizing Natural History: Berkeley's Museum of Vertebrate Zoology in Transition.

Throughout the twentieth century calls to modernize natural history motivated a range of responses. It was unclear how research in natural history museums would participate in the significant technological and conceptual changes that were occurring in the life sciences. By the 1960s, the Museum of Vertebrate Zoology at the University of California, Berkeley, was among the few university-based natural history museums that were able to maintain their specimen collections and support active research.

Collections-Based Research at Berkeley’s Museum of Vertebrate Zoology.

Unlabelled: [[

Keywords: Alden Holmes Miller, natural history, collections, museum, ornithology, evolution, fieldwork, Berkeley, collections-based research, Museum of Vertebrate Zoology ]] Recognizing natural history collections as dynamic scientific tools that enable unique forms of comparative analysis, theorizing, and questioning offers a new perspective on the history of the life sciences in the twentieth century that emphasizes the important role that collections played in the transformation of biology. To build an understanding of “collections-based research,” this paper focuses on the career of Alden Holmes Miller, who led the Museum of Vertebrate Zoology at the University of California, Berkeley through significant institutional, disciplinary, and technological changes (1940–1965). This paper examines how Miller’s efforts as researcher, administrator, and teacher enabled him to foster collections-based research.

Morphogenesis, Dictyostelium, and the search for shared developmental processes.

In the 1930s John Tyler Bonner began studying the slime mold, Dictyostelium discoideum, as a way to investigate how organisms develop. With a life cycle that includes periods of unicellularity and multicellularity, Dictyostelium raises questions fundamental to development and evolution. In Morphogenesis: An Essay on Development (1952), Bonner built on his work with Dictyostelium to inform developmental theory and practice.

Regeneration: Thomas Hunt Morgan's window into development.

Early in his career Thomas Hunt Morgan was interested in embryology and dedicated his research to studying organisms that could regenerate. Widely regarded as a regeneration expert, Morgan was invited to deliver a series of lectures on the topic that he developed into a book, Regeneration (1901). In addition to presenting experimental work that he had conducted and supervised, Morgan also synthesized and critiqued a great deal of work by his peers and predecessors.

The ethos and ethics of translational research.

Calls for the "translation" of research from bench to bedside are increasingly demanding. What is translation, and why does it matter? We sketch the recent history of outcome-oriented translational research in the United States, with a particular focus on the Roadmap Initiative of the National Institutes of Health (Bethesda, MD). Our main example of contemporary translational research is stem cell research, which has superseded genomics as the translational object of choice.

The proliferation and expansion of retinal stem cells require functional Pax6.

Retinal stem cells (RSCs) exist as rare pigmented ciliary epithelial cells in adult mammalian eyes. We hypothesized that RSCs are at the top of the retinal cell lineage. Thus, genes expressed early in embryonic development to establish the retinal field in forebrain neuroectoderm may play important roles in RSCs.