Machine learning-based clustering and classification of mouse behaviors via respiratory patterns.

Breathing is dynamically modulated by metabolic needs as well as by emotional states. Even though rodents are invaluable models for investigating the neural control of respiration, current literature lacks systematic characterization of breathing dynamics across a broad spectrum of rodent behaviors. Here we uncover a wide diversity in breathing patterns across spontaneous, attractive odor-, stress-, and fear-induced behaviors in mice.

State-dependent olfactory processing in freely behaving mice.

Decreased responsiveness to sensory stimuli during sleep is presumably mediated via thalamic gating. Without an obligatory thalamic relay in the olfactory system, the anterior piriform cortex (APC) is suggested to be a gate in anesthetized states. However, olfactory processing in natural sleep states remains undetermined.