Publications by authors named "Mary N Walter"
Background: It is well established that females are more susceptible to the toxic effects of alcohol, although the exact mechanisms are still poorly understood. Previous studies noted that alcohol reduces the expression of mitogen-activated protein kinase phosphatase 1 (MKP1), a negative regulator of mitogen-activated protein kinases (MAPK) in the liver. However, the role of hepatocyte- specific MKP1 in the pathogenesis of alcohol-associated liver disease (ALD) remains uncharacterized.
View Article and Find Full Text PDFBackground: Cyclic nucleotides are second messengers, which play significant roles in numerous biological processes. Previous work has shown that cAMP and cGMP signaling regulates various pathways in liver cells, including Kupffer cells, hepatocytes, hepatic stellate cells, and cellular components of hepatic sinusoids. Importantly, it has been shown that cAMP levels and enzymes involved in cAMP homeostasis are affected by alcohol.
View Article and Find Full Text PDFArticle Synopsis
- Rising obesity rates are linked to an increase in early-onset colorectal cancer, with specific cytokine expressions impacting patient survival.
- Researchers examined how the obesity hormone leptin and the macrophage metabolite itaconate affect important cellular mechanisms related to this cancer type.
- Results showed that itaconate significantly downregulated peroxisome proliferator activated receptor gamma while elevating anti-inflammatory cytokines, suggesting it might play a crucial role in linking obesity to early-onset colorectal cancer.