Publications by authors named "Mary Mansfield"
Article Synopsis
- CAPA, or COVID-19-associated pulmonary aspergillosis, occurs in patients with severe SARS-CoV-2 infections and has a high mortality rate of about 50%, complicated by azole resistance.
- A genomic analysis of 21 CAPA isolates from four European countries revealed a 14.3% prevalence of azole resistance, all linked to known genetic mutations.
- The findings suggest that monitoring for resistant strains and potentially updating antifungal treatment guidelines could improve patient outcomes among those suspected of having CAPA.
The aim of this study was to evaluate the performance of Xpert MTB/RIF Ultra (Ultra) compared with its predecessor, Xpert MTB/RIF (Xpert), in the diagnosis of tuberculosis (TB) in a low TB incidence country. Retrospective analysis was performed on 689 clinical samples received between 2015 and 2018, on which Xpert was performed, and on 715 samples, received between 2018 and 2020, on which Ultra was performed. Samples were pulmonary ( = 830) and extrapulmonary ( = 574) in nature, and a total of 264 were culture positive for Mycobacterium tuberculosis complex (MTBC).
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