Publications by authors named "Mary Mangione"
Article Synopsis
- The objective of the study was to explore the signaling pathways originating from the placenta that contribute to spontaneous preterm labor, using advanced techniques like single-cell RNA sequencing.
- Researchers found that specific pathways, such as ferroptosis and kisspeptin, were activated in distinct cellular clusters of the placenta from preterm births, with a notable increase in the gene PSG4 related to cellular aging.
- The study concludes that the overexpression of PSG4 could serve as a valuable biomarker for identifying pregnant women at higher risk of preterm delivery, potentially aiding in early interventions.
Objectives: Many physiological adaptations occur during pregnancy. It is not currently known how timing of COVID-19 infection impacts pregnancy. We hypothesize that maternal and neonatal outcomes are different if COVID-19 infection occurs in different trimesters of pregnancy.
View Article and Find Full Text PDFObjectives: This study aimed to evaluate the temporal trend of novel coronavirus disease 2019 (COVID-19) symptoms and severity of clinical outcomes among pregnant women over a calendar year in the State of Maryland and compare clinical outcomes between different ethnic and racial groups.
Study Design: We conducted a retrospective, multicenter observational study of the temporal trend of COVID-19 clinical presentation during pregnancy in the State of Maryland. We reviewed consecutive charts of adult pregnant females, aged 18 to 55 years, with laboratory-confirmed severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection between March 1, 2020, and February 28, 2021, and managed within the University of Maryland Medical System and Johns Hopkins Medicine.