The Impact of a Human Figure in a Scene on Spatial Descriptions in Speech, Gesture, and Gesture Alone.

The presence of a human figure in a scene appears to change how people describe it. About 20% of participants take the human figure's viewpoint (Tversky and Hard in Cognition 110:124-129, 2009. http://doi.

In prostate cancer C/EBPalpha promotes cell growth by the loss of interactions with CDK2, CDK4, and E2F and by activation of AKT.

Background: The CCAAT/Enhancer binding protein alpha (C/EBPalpha) is an important transcription factor for granulopoiesis and adipogenesis. While decreased expression and mutation of C/EBPalpha has been found in several types of tumors, the role of C/EBPalpha in prostate cancer has not been well characterized.

Methods: We quantitatively analyzed the immunochemical staining of prostate cancer tissue and examined the growth properties of prostate cancer cells stably expressing C/EBPalpha by measure growth curve, cell cycle, and anchorage independent colony formation, investigated the association of C/EBPalpha with E2Fs and CDKs by co-immunoprecipitation and examined the expression of CDKs and activation of AKT by Western blot analysis.

MG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytes.

BACKGROUND: Although chromosome missegregation during oocyte maturation (OM) is a significant contributor to human morbidity and mortality, very little is known about the causes and mechanisms of aneuploidy. Several investigators have proposed that temporal perturbations during OM predispose oocytes to aberrant chromosome segregation. One approach for testing this proposal is to temporarily inhibit the activity of protein proteolysis during OM.