Improved pharmacy department workflow with new method of order entry for single-agent, high-dose methotrexate.

Purpose: To determine whether a process change impacted the proportion of orders for single-agent, high-dose methotrexate entered by chemotherapy pharmacists instead of general pharmacy staff. Coordination of antiemetic premedication and leucovorin rescue with the new method of order entry was evaluated.

Methods: Adults treated with single-agent, high-dose methotrexate were identified retrospectively.