Publications by authors named "Mary Kozlak"
In earlier work we assembled a database of classical pharmacokinetic parameters (e.g., elimination half-lives; volumes of distribution) in children and adults.
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- Pharmacokinetics of xenobiotics vary significantly between children and adults due to differences in physiology and immature enzyme systems, making adult dosage estimates for children uncertain.
- A Children's PK Database was created, comparing pharmacokinetic parameters for 45 drugs between children and adults, showing that neonates generally have a longer half-life for these drugs, which normalizes by 2-6 months of age.
- The findings indicate that the typical uncertainty factor used for interindividual variability may be insufficient for certain drugs during early infancy, suggesting the need for tailored risk assessment approaches for children regarding environmental toxicants.