Publications by authors named "Mary K Stone"
Article Synopsis
- Monoclonal antibody therapy, specifically elotuzumab targeting the CS1 protein, shows promise for treating multiple myeloma, a type of blood cancer, despite previous challenges due to a lack of suitable targets.
- Elotuzumab was found to effectively kill myeloma cells in bone marrow environments and its efficacy could be boosted when combined with bortezomib, a drug that inhibits proteasomes and is already used in myeloma treatment.
- The study suggests that a clinical trial should test the combination of elotuzumab and bortezomib to potentially improve treatment outcomes for patients with relapsed or refractory multiple myeloma.
Tracheal gas insufflation (TGI) flushes expired gas from the ventilator circuitry and central airways, augmenting CO2 clearance. Whereas a significant portion of this washout effect may occur distal to the injection orifice, the penetration and mixing behavior of TGI gas has not been studied experimentally. We examined the behavior of 100% oxygen TGI injected at set flow rates of 1-20 l/min into a simulated trachea consisting of a smooth-walled, 14-mm-diameter tube.
View Article and Find Full Text PDFOscillations and noise: inherent instability of pressure support ventilation?
Am J Respir Crit Care Med
January 2002
Pressure support ventilation (PSV) is almost universally employed in the management of actively breathing ventilated patients with acute respiratory failure. In this partial support mode of ventilation, a fixed pressure is applied to the airway opening, and flow delivery is monitored by the ventilator. Inspiration is terminated when measured inspiratory flow falls below a set fraction of the peak flow rate (flow cutoff); the ventilator then cycles to a lower pressure and expiration commences.
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