Publications by authors named "Mary K Miranowski"
Background: Arginine-supplemented enteral immunonutrition has been designed to optimize outcomes in critical care patients. Existing formulas may be isocaloric and isoproteic, yet differ in L-arginine content, energy distribution, and in source and amount of many other specialized ingredients. The individual contributions of each may be difficult to pinpoint; however, all cumulate in the body's response to illness and injury.
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- This study investigates the relationship between enteral nutrition (EN) formulas and gastrointestinal (GI) intolerance in critically ill hospitalized patients.
- It analyzes data from nearly 20,000 inpatients across 67 hospitals, comparing patients on different EN formulas, particularly focusing on 100% whey-peptide, other peptide-based, and standard intact-protein diets.
- Results indicate that patients on the 100% whey-peptide formula experienced lower rates of GI intolerance and hyperglycemia compared to those on other peptide-based and standard methods, despite having more severe illnesses.
High-protein enteral nutrition is advised for patients who are critically ill. Options include immunonutrition formulas of various compositions and standard high-protein formulas (StdHP). Additional research is needed on the health economic value of immunonutrition in a broad cohort of severely ill hospitalized patients.
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