Publications by authors named "Mary Grace Lin"
Article Synopsis
- The primary cilium is a key organelle involved in sensory functions and signaling, and issues in its formation can lead to genetic disorders called ciliopathies.
- The study reveals that autophagy, a cellular degradation process, is essential for removing the ciliopathy protein OFD1 from centriolar satellites, facilitating the formation of primary cilia.
- By manipulating OFD1 levels, researchers found that enhancing or reducing its presence can significantly influence cilia development in normal and cancer cells, highlighting autophagy's important role in the biogenesis of organelles.
Article Synopsis
- * Problems in how endosomes and autophagosomes mature can lead to diseases like cancer, but the specific molecular mechanisms behind this are not fully understood.
- * Recent research shows that Rubicon, part of the PI3KC3 complex, inhibits endosome maturation by blocking the activation of a key GTPase called Rab7, suggesting new models for how these processes might interact.
