Publications by authors named "Mary Fenna"
This article reports on the construction and analysis in vitro and in vivo of novel gene switches that can be used to achieve spatial as well as temporal control over the expression of a transgene of interest. The switches are expected to be functional in virtually any tissue and cell type. They consist of (a) a foreign or modified transactivator expressed under the dual control of a promoter or promoter cassette that is responsive to heat and the transactivator and (b) a promoter responsive to the transactivator for controlling the transgene of interest.
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- DAXX interacts with the trimeric form of human heat shock factor 1 (HSF1) during stress, suggesting it plays a key role in activating HSF1.
- Overexpression of DAXX boosts HSF1's transactivation ability, while its depletion leads to reduced activation and heat shock protein (HSP)70 expression.
- The study proposes that DAXX may counteract repression of HSF1 by a multichaperone complex, revealing its potential impact on heat shock protein modulation.