Measurement of endocervical canal extension of the transformation zone on fresh hysterectomy specimens.

Objective: Determine the extent of endocervical canal extension of the transformation zone on fresh hysterectomy specimens.

Materials And Methods: After removal for standard gynecologic indications, 201 uteri were evaluated in the pathology accessioning area of a community hospital before formalin fixation. Uteri were opened in standard fashion.

Biopsy site selection during colposcopy and distribution of cervical intraepithelial neoplasia.

Objective: To determine if sites selected for colposcopic biopsy and histologically proven cervical intraepithelial neoplasia are distributed randomly across the cervix.

Materials And Methods: Data were evaluated from all patients who visited the Walter Reed Army Medical Center Colposcopy Clinic during a 20-month period. chi analysis was performed to assess the randomness of distribution of biopsies and cervical intraepithelial neoplasia.

Initial neural net construction for the detection of cervical intraepithelial neoplasia by fluorescence imaging.

Objective: The aim of this study was to initiate neural net construction for the detection of cervical intraepithelial neoplasia by fluorescence imaging.

Study Design: Thirty-three women with abnormal Papanicolaou smears underwent fluorescence imaging during colposcopy. With the use of >4000 training pixels and >1000 test pixels, intrapatient nets were constructed from the spectral data of 17 women.

Discrepancy in the interpretation of cervical histology by gynecologic pathologists.

Objective: To determine if subspecialty review of cervical histology improves diagnostic consensus of cervical intraepithelial neoplasia (CIN).

Methods: After routine histologic assessment within the hospital pathology department, 119 colposcopic cervical biopsies were interpreted by two subspecialty-trained gynecologic pathologists (GYN I and GYN II) blinded to each other's interpretations and to the interpretations of the hospital general pathologists (GEN). Biopsies were classified as normal (including cervicitis), low grade (LG, including CIN I and human papillomavirus changes), and high grade (HG, including CIN II/III).