Publications by authors named "Mary Erb"
Native platelets perform a number of functions within the wound healing process, including interacting with fibrin fibers at the wound site to bring about retraction after clot formation. Clot retraction improves clot stability and enhances the function of the fibrin network as a provisional matrix to support cellular infiltration of the wound site, thus facilitating tissue repair and remodeling after hemostasis. In cases of traumatic injury or disease, platelets can become depleted and this process disrupted.
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- A fibrin-rich matrix forms after an injury to stop bleeding and support healing, but issues with fibrin network formation can lead to poor healing, especially in hemophilia.
- Platelet-like particles (PLPs) mimic platelet functions, enhancing clotting and aiding in wound healing by binding to fibrin and facilitating clot retraction.
- The study showed that PLPs improved the quality of clot networks and promoted cell migration in a hemophilia model, suggesting they could help improve healing in conditions with impaired fibrin formation.
Native platelets perform several critical functions within the context of wound healing, including participating in initial hemostasis and interacting with fibrin at the wound site to induce clot retraction. Platelet depletion or dysfunction due to trauma or disease can inhibit robust wound healing responses. There has been a focus recently on developing synthetic, non-immunogenic platelet mimetic technologies for the purpose of augmenting hemostatic responses in cases of deficient native platelet functionality.
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