Publications by authors named "Mary E Harrod"

Article Synopsis
  • Cannabis use disorder (CUD) is becoming more prevalent, leading to various health and social issues, and a Phase IIa trial showed that cannabidiol (CBD) could effectively reduce non-prescribed cannabis use.
  • A Phase III clinical trial will evaluate the long-term effects of CBD treatment on patients with moderate-to-severe CUD over 12 weeks, with follow-ups at 24 weeks, involving 250 participants from multiple clinics in Australia.
  • The trial will assess both primary (self-reported cannabis use and urine analysis) and secondary endpoints (including severity of CUD, withdrawal symptoms, quality of life, etc.), along with qualitative interviews with Aboriginal participants for insight into their treatment experiences.
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Introduction: Research into stigma and injecting drug use has typically involved predominantly male participants, with limited research about the unique experience of women who inject drugs.

Methods: This study used survey methods to assess reduced access to health care due to stigma among a sample of women who inject drugs. Women (n = 232) completed a survey as part of a broader national study of people who inject drugs.

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Article Synopsis
  • The study examined a single-visit test and treatment approach for hepatitis C virus (HCV) among individuals with recent injecting drug use, integrating point-of-care RNA testing, nursing support, and peer engagement at a needle and syringe program in Sydney, Australia.
  • Of the 101 participants, 27% tested positive for HCV RNA, with a treatment initiation rate of 74%; most initiated treatment within a few days of testing.
  • The overall treatment completion rate was 60%, with a high sustained virological response rate of 89% among those who were evaluated, demonstrating the effectiveness of this intervention in improving HCV treatment access.
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Background: New technologies and therapies allow the possibility of a single-visit test and treat model for hepatitis C virus (HCV), addressing some of the barriers to care faced by people who inject drugs.

Methods: The TEMPO Pilot Study was an interventional cohort study evaluating a single-visit test and treat intervention among people with recent injecting drug use at a one peer-led needle and syringe program (NSP) in Sydney, Australia between September 2019 and February 2021. This analysis evaluated awareness of HCV status and agreement of self-report with HCV RNA test results.

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Introduction: Prompt help-seeking behaviour by music festival attendees can reduce risks associated with drug use; however, little is known about perceived barriers to help-seeking when experiencing or witnessing illness at music festivals. We explored potential barriers and their association with festivalgoer characteristics.

Methods: We conducted an on-site cross-sectional survey of attendees at New South Wales music festivals in 2019/2020.

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Introduction: Naloxone is a life-saving medication that reverses opioid overdose; naloxone can be provided on a 'take-home' basis so naloxone can be administered outside of the health-care setting. The Overdose Response and Take Home Naloxone (ORTHN) project established a model of care for take-home naloxone (THN) interventions across alcohol and other drug and harm reduction services in NSW, Australia. This paper evaluates the staff training and credentialing program, and examines staff attitudes and perspectives regarding the provision of THN interventions in these settings.

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Introduction: There are few contemporary data on illicit drug use at music festivals. We describe drug use patterns and prevalence of specific higher-risk drug-related behaviours, and their associations with festivalgoer characteristics.

Methods: We approached attendees at six major music festivals in New South Wales, Australia, from November 2019 to March 2020.

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Introduction: Implementation of wastewater surveillance at music festivals has been limited to date. We aimed to use wastewater analysis and a self-report survey to determine the range of psychoactive substances being used during a music festival season in New South Wales, Australia.

Methods: We sampled six single-day music festivals requiring a music festival license in New South Wales from March 2019 to March 2020; between 15% and 100% of portaloos (temporary, un-fixed toilet facilities) were sampled at each festival.

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Background And Objectives: Pre-donation screening of potential blood donors is critical for ensuring the safety of the donor blood supply, and donor deferral as a result of risk factors is practised worldwide. This systematic review was conducted in the context of an expert review convened by the Australian Red Cross Lifeblood in 2013 to consider Lifeblood's injecting drug use (IDU)-related policies and aimed to identify studies assessing interventions to improve compliance with deferral criteria in blood donation settings.

Materials And Methods: MEDLINE/PubMed, OVID Medline, OVID Embase, LILACS, and the Cochrane Library (CENTRAL and DARE) databases were searched for studies conducted within blood donation settings that examined interventions to increase blood donor compliance with deferral criteria.

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Article Synopsis
  • Take-home naloxone (THN) interventions effectively prevent overdose deaths, but their use in Australia is still low; this project aimed to create a model (ORTHN) specifically for opioid users attending treatment and health services.* -
  • The ORTHN model involved training clients and providing naloxone via a collaborative effort from service providers and health workers; it was implemented in over 15 services in New South Wales, with evaluations done on participants' knowledge and experiences before and after the intervention.* -
  • Results showed positive outcomes with improved attitudes toward overdose response, a significant number of participants successfully reversing overdoses, and an indication of willingness to access THN services, suggesting that the ORTHN model could effectively promote
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Introduction: One of the current harm reduction debates in Australia concerns the legalisation of the extended distribution of sterile needles and syringes, a practice that is currently unlawful in most Australian settings.

Methods: We used data from a unique pilot program of authorised extended distribution to document the opinions held by 22 key stakeholders -service staff, drug users and police - about the risks and benefits of authorisation, and to analyse the ways in which drug users were understood within these.

Results: Opinions were strongly in favour of authorising extended distribution, based on the belief that this would reduce the transmission of hepatitis C.

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Unlabelled: Background People who inject drugs (PWID) are a priority for HIV prevention. This study aimed to determine perceptions, potential eligibility and willingness to use PrEP among PWID in Sydney.

Methods: Clients completed a cross-sectional survey to collect data on demographics, perceived risk of HIV and willingness to use PrEP, which were then analysed.

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Article Synopsis
  • The study examines the prevalence trends of hepatitis B markers among Indigenous and non-Indigenous prison entrants from 2004 to 2013, highlighting significant differences in infection rates.
  • Indigenous entrants showed higher rates of hepatitis B core antibody positivity initially, but the prevalence among them declined significantly by 2013, equalizing with non-Indigenous entrants.
  • The research identifies unique risk factors for HBV among both Indigenous and non-Indigenous populations, emphasizing the need for tailored public health initiatives addressing these differences.
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Background: Extended distribution refers to the practice whereby people who inject drugs pass on sterile injecting equipment to their networks and can be a means to access people who inject drugs who do not attend state-sanctioned needle and syringe programs. While it is legal, to possess a sterile syringe for the purpose of injecting drugs in New South Wales, Australia, it is a criminal offence to pass this equipment on for others to use. In 2013 a pilot project was established to trial the authorization of "extended" peer distribution.

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Unlabelled: Background Gonorrhoea occurs at high levels in young Aboriginal and Torres Strait Islander people living in remote communities, but there are limited data on urban and regional settings. An analysis was undertaken of gonorrhoea testing and positivity at four non-remote Aboriginal Community Controlled Health Services participating in a collaborative research network.

Methods: This was a retrospective analysis of clinical encounter data derived from electronic medical records at participating services.

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Objective: Hepatitis B virus (HBV) infection remains an important cause of morbidity and mortality in Aboriginal and Torres Strait Islander people, who have high rates of infection compared with non-Indigenous Australians. We aimed to increase the evidence base around HBV in Aboriginal and Torres Strait Islander people through an analysis of routine clinical encounter data.

Design: A cross-sectional study of de-identified records from electronic patient systems over 5 years (8 January 2009 to 11 July 2013).

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Adherence to medical treatment is an ongoing challenge for families and young people with chronic medical conditions. One factor that is likely to influence treatment success is the quality of professional relationships both within the health care team and between the family, child and professionals. This paper explores the topic of professional relationships and adherence and provides an example of how a multidisciplinary team can improve the health and quality of life of paediatric patients.

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The Australian Government has an extensive stockpile of antivirals (neuraminidase inhibitors) to be used if an influenza pandemic occurs. Neuraminidase inhibitors reduce the duration of the symptoms of seasonal influenza infection by 1 day on average, when used as treatment within 48 hours of disease onset. Neuraminidase inhibitors prevent infection in up to 74% of people when administered as prophylaxis.

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It has been estimated that there may be as many as 150,000 healthcare associated infections (HCAI) in Australia each year, contributing to 7,000 deaths, many of which could be prevented through the implementation of appropriate infection control practices. Contact with contaminated hands is a primary source of HCAI. Intensive care staff have been identified as one of the least adherent groups of health care professionals with handwashing; they are less likely to practise hand antisepsis before invasive procedures than staff working in other patient care specialties.

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This study examined variability in handwashing policy between hospitals, variability in handwashing practices in nurses and how practice differed from policy in tertiary paediatric hospitals in Australia and New Zealand. Eight of the possible nine major paediatric hospitals provided a copy of their handwashing and/or central venous access device (CVAD) policies, and 67 nurses completed a survey on their handwashing practices associated with CVAD management. A high degree of variability was found in relation to all the questions posed in the study.

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