Dephosphorylation of 4EBP1/2 Induces Prenatal Neural Stem Cell Quiescence.

A limiting factor in the regenerative capacity of the adult brain is the abundance and proliferative ability of neural stem cells (NSCs). Adult NSCs are derived from a subpopulation of embryonic NSCs that temporarily enter quiescence during mid-gestation and remain quiescent until postnatal reactivation. Here we present evidence that the mechanistic/mammalian target of rapamycin (mTOR) pathway regulates quiescence entry in embryonic NSCs of the developing forebrain.

The presence of placeholders modulates the naso-temporal asymmetry in the remote distractor effect.

The remote distractor effect (RDE) is a well-known and robust phenomenon whereby latencies of saccades are increased when a distractor is presented simultaneously along with the saccade target. Studies of the RDE in patients with a loss of vision in one visual field (hemianopia) following damage to primary visual cortex have provided conflicting results. Rafal, Smith, Krantz, Cohen, and Brennan (1990) reported a naso-temporal asymmetry in the RDE in patients with hemianopias, with a greater influence of distractors presented in their blind temporal visual field.