A Randomized, Crossover Trial of a Novel Sound-to-Sleep Mattress Technology in Children with Autism and Sleep Difficulties.

Study Objectives: This preliminary study investigated the tolerability and efficacy of a novel mattress technology-the Sound-To-Sleep (STS) system-in the treatment of sleep problems in children with autism.

Methods: After screening, 45 children, ages 2.5 to 12.

Development of an Objective Autism Risk Index Using Remote Eye Tracking.

Objective: Abnormal eye gaze is a hallmark characteristic of autism spectrum disorder (ASD), and numerous studies have identified abnormal attention patterns in ASD. The primary aim of the present study was to create an objective, eye tracking-based autism risk index.

Method: In initial and replication studies, children were recruited after referral for comprehensive multidisciplinary evaluation of ASD and subsequently grouped by clinical consensus diagnosis (ASD n = 25/15, non-ASD n = 20/19 for initial/replication samples).

Metabolite Profiles of the Serum of Patients with Non-Small Cell Carcinoma.

Introduction: Alterations of serum metabolites may allow us to identify individuals with lung cancer and advance our understanding of the nature and treatment of their cancer. We aimed to identify serum metabolites that differentiate patients with lung cancer from at-risk controls.

Methods: Serum samples from patients with biopsy-confirmed untreated stage I through stage III non-small cell lung cancer and at-risk controls were divided into fractions for analysis by ultrahigh-performance liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry.

Accuracy of volatile urine biomarkers for the detection and characterization of lung cancer.

Background: The mixture of volatile organic compounds in the headspace gas of urine may be able to distinguish lung cancer patients from relevant control populations.

Methods: Subjects with biopsy confirmed untreated lung cancer, and others at risk for developing lung cancer, provided a urine sample. A colorimetric sensor array was exposed to the headspace gas of neat and pre-treated urine samples.

Progress in the development of volatile exhaled breath signatures of lung cancer.

Rationale: Volatile organic compounds present in the exhaled breath have shown promise as biomarkers of lung cancer. Advances in colorimetric sensor array technology, breath collection methods, and clinical phenotyping may lead to the development of a more accurate breath biomarker.

Objectives: Perform a discovery-level assessment of the accuracy of a colorimetric sensor array-based volatile breath biomarker.

The effect of metformin and thiazolidinedione use on lung cancer in diabetics.

Background: Metformin and the thiazolidinediones (TZDs) may have a protective effect against the development of lung cancer.

Methods: Patients with diabetes mellitus (DM) were identified from the electronic medical records of the Cleveland Clinic. Diabetics with lung cancer were identified then verified by direct review of their records.

Exhaled breath analysis with a colorimetric sensor array for the identification and characterization of lung cancer.

Introduction: The pattern of exhaled breath volatile organic compounds represents a metabolic biosignature with the potential to identify and characterize lung cancer. Breath biosignature-based classification of homogeneous subgroups of lung cancer may be more accurate than a global breath signature. Combining breath biosignatures with clinical risk factors may improve the accuracy of the signature.