Publications by authors named "Mary B Rowland"
Article Synopsis
- - The endoplasmic reticulum (ER) plays a crucial role in protein synthesis and folding, utilizing specific sensors to detect stress from misfolded proteins through the unfolded protein response (UPR).
- - The UPR initially initiates protective responses to manage stress but can lead to cell death (apoptosis) if stress conditions persist without recovery.
- - This review focuses on the harmful aspects of UPR in cardiac fibroblasts (CFs) and explores potential treatments to combat UPR-induced apoptosis, which is linked to the development of heart conditions like cardiac fibrosis.
Article Synopsis
- Defects in myofibroblast function can lead to issues with wound healing across different tissue types.
- The study introduces an easy method using skin-punch biopsies in mouse models to identify wound closure problems without needing advanced surgical skills or costly tools.
- Results from this approach could provide a basis for deciding whether to investigate further into how myofibroblast function defects impact skin wound healing.
Coral disease is a major threat to reef ecosystems and therefore, understanding the cellular pathways underlying disease progression and resistance is critical to mitigating future outbreaks. This study focused on tyrosinase-like proteins in cnidarians, which contribute to melanin synthesis, an invertebrate innate immune defense. Specifically, characterization and phylogenetic analysis of cnidarian tyrosinases were performed, and their role in symbiosis and a "mystery disease" in the anemone Exaiptasia pallida was investigated using qPCR.
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