Publications by authors named "Mary B McCoy"
Transcription factor proteins bind to specific DNA promoter sequences and initiate gene transcription. These proteins often contain intrinsically disordered activation domains (ADs) that regulate their transcriptional activity. Like other disordered protein regions, ADs do not have a fixed three-dimensional structure and instead exist in an ensemble of conformations.
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- Transcription factors bind to DNA and kickstart gene transcription, often featuring disordered regions called activation domains (ADs) that affect their functionality.
- These ADs don’t have a fixed shape; instead, they exist in multiple conformations that are influenced by their amino acid sequences.
- In a study measuring the structural dimensions of two ADs (HIF-1α and CITED2) using FRET microscopy, it was found that altering the shape of HIF-1α influenced its ability to activate transcription, while CITED2's activity remained unaffected by its structural changes.