Publications by authors named "Mary Anne M Morgan"
Background: Experimental studies demonstrate beneficial immunological and hemodynamic effects of estradiol in animal models of sepsis. This raises the question whether estradiol contributes to sex differences in the incidence and outcomes of sepsis in humans. Yet, total estradiol levels are elevated in sepsis patients, particularly nonsurvivors.
View Article and Find Full Text PDFObjective: Sepsis is characterized by microvascular dysfunction and thrombophilia. Several methionine metabolites may be relevant to this sepsis pathophysiology. S-adenosylmethionine (SAM) serves as the methyl donor for trans-methylation reactions.
View Article and Find Full Text PDFObjectives: Arginine deficiency may contribute to microvascular dysfunction, but previous studies suggest that arginine supplementation may be harmful in sepsis. Systemic arginine availability can be estimated by measuring the ratio of arginine to its endogenous inhibitors, asymmetric and symmetric dimethylarginine. We hypothesized that the arginine-to-dimethylarginine ratio is reduced in patients with severe sepsis and associated with severity of illness and outcomes.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates the role of nitric oxide deficiency in microvascular dysfunction during sepsis, suggesting that nitrite and S-nitrosohemoglobin may aid in nitric oxide delivery within the body.
- In a controlled environment with critically ill septic patients and healthy controls, researchers measured nitrite and S-nitrosohemoglobin levels in both arterial and venous blood.
- Results indicated that healthy individuals showed significant differences in these levels between arterial and venous blood, while septic patients displayed diminished differences, correlating with higher mortality when arterial plasma nitrite levels were low.