Publications by authors named "Mary Ann Lou"
Article Synopsis
- The study analyzed mitochondrial DNA (mtDNA) content in 302 pairs of breast tumors and surrounding normal tissues, revealing that tumor tissues generally have much lower mtDNA levels than normal tissues.
- As tumor size increases, the mtDNA content decreases, but in very large tumors, the mtDNA content increases again.
- Variations in mtDNA content are linked to tumor grade and genetic alterations, with abnormal levels of mtDNA associated with a higher risk of death for patients compared to those with median levels.
Article Synopsis
- Immunohistochemistry and immunoblotting of 183 breast cancer samples show Tid1 and CHIP expression positively correlates with each other but inversely with ErbB2, indicating their potential as biomarkers.
- Lower expressions of Tid1 and CHIP are associated with worse tumor grades and clinical outcomes, while their presence improves long-term survival rates, suggesting their crucial role in regulating ErbB2 degradation.
Article Synopsis
- The Subcutaneous Intravenous Infusion Port (SIIP) is increasingly used for managing oncology patients, serving various purposes like chemotherapy, nutrition, blood transfusions, and more.
- A review of 1247 breast cancer patients from 1990 to 2008 shows that complications related to SIIP decrease as surgical techniques improve.
- The study aims to share insights and enhancements in SIIP procedures to assist new surgeons in the field.
Article Synopsis
- Intestinal Behçet's disease is characterized by multiple and easily perforating intestinal ulcers, often requiring emergency surgery to address these complications.* ! -
- The study followed 125 cases over 25 years, focusing on 82 patients with intestinal involvement, where 22 experienced serious perforations necessitating surgical intervention.* ! -
- Surgical procedures varied, including right hemicolectomy and ileocecal resections, and analysis was done on demographics, clinical features, lab results, and surgical outcomes of the patients.* !
Article Synopsis
- * Results showed significant AIB1 gene amplifications in 22% of estrogen receptor-positive breast cancer cell lines, with no amplifications in estrogen receptor-negative lines, indicating a possible link between AIB1 amplification and hormonal status.
- * Although the sequencing of poly Q regions did not show specific patterns associated with gene amplification, many breast cancer cell lines displayed variations suggesting somatic instability, particularly within MCF-7 cell derivatives.
RER and LOH association with sporadic colorectal cancer in Taiwanese patients.
Hepatogastroenterology
November 2002
Article Synopsis
- The study aimed to investigate replication error and loss of heterozygosity in colorectal tumors using 10 microsatellite markers related to various tumor suppressor genes.
- Thirty-nine patients with sporadic colorectal cancer were analyzed through biopsied frozen tissues to determine genomic instability using an automated fluorescent microsatellite assay.
- Results indicated that replication errors were present in 20.5% of cases, with higher occurrences in younger patients, while significant loss of heterozygosity was found at genes such as P53, DCC, and APC, correlating with patient survival outcomes, particularly in male patients.