Results of the veterinary enalapril trial to prove reduction in onset of heart failure in dogs chronically treated with enalapril alone for compensated, naturally occurring mitral valve insufficiency.

Objective: To determine the efficacy of long-term enalapril administration in delaying the onset of congestive heart failure (CHF).

Design: Placebo-controlled, double-blind, multicenter, randomized trial.

Animals: 124 dogs with compensated mitral valve regurgitation (MR).

Effects of long-term administration of enalapril on clinical indicators of renal function in dogs with compensated mitral regurgitation.

Objective: To determine the effect of long-term administration of enalapril on renal function in dogs with severe, compensated mitral regurgitation.

Design: Randomized controlled trial.

Animals: 139 dogs with mitral regurgitation but without overt signs of heart failure.