First endoluminal system for transmural resection of colorectal tissue with a prototype full-thickness resection device in a porcine model.

Background: Endoluminal transmural resection of colorectal lesions is a pivotal advance in endoscopic technology. A full-thickness resection device has been developed that functions through a combination of tissue grasping, stapling, and cutting under endoscopic guidance. This preclinical study evaluated the performance, safety, and effectiveness of the full-thickness resection device in a porcine model.