Publications by authors named "Mary A Elrick"
Article Synopsis
- Effector CD8(+) T cells are crucial for fighting viral infections and monitoring tumors, but their survival and function can be influenced by factors like stress and inflammation.
- Researchers created a special mouse model to explore the role of autophagy in T cell responses during viral infections, specifically using influenza as a case study.
- Their findings revealed that a lack of autophagy (due to Atg5 deletion) led to reduced T cell effectiveness, increased cell death, and failure to develop long-term immunity after secondary infections, highlighting the importance of autophagy in T cell survival and function.
Background: When T cells infiltrate the tumor environment they encounter a myriad of metabolic stressors including hypoxia. Overcoming the limitations imposed by an inadequate tumor vasculature that contributes to these stressors may be a crucial step to immune cells mounting an effective anti-tumor response. We sought to determine whether the functional capacity of tumor infiltrating lymphocytes (TIL) could be influenced by the tumor vasculature and correlated this with survival in patients with ovarian cancer.
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