Relative fitness of wild-type and phage-resistant pyomelanogenic and effects of combinatorial therapy on resistant formation.

Bacteriophages, the natural predators of bacteria, are incredibly potent candidates to counteract antimicrobial resistance (AMR). However, the rapid development of phage-resistant mutants challenges the potential of phage therapy. Understanding the mechanisms of bacterial adaptations to phage predation is crucial for phage-based prognostic applications.

Formulation of Dual-Functional Nonionic Cetomacrogol Creams Incorporated with Bacteriophage and Human Platelet Lysate for Effective Targeting of MDR and Enhanced Wound Healing.

Successful development of phage-based therapeutics and their utility predominantly depend on the mode and route of phage administration. Topical and site-directed phage application evokes minimal immune clearance and allows more phage-host adsorption, thereby ensuring higher phage efficacy. However, a notable drawback of conventional topical phage applications is the absence of sustained release.

Positive effect of a diggable substrate on the behaviour of a captive naked mole rat colony.

Naked mole rats (Heterocephalus galber) are eusocial mammals from East Africa. Their extraordinary social organisation is accompanied by remarkable adaptations to an underground lifestyle, extreme longevity and resistance to many diseases, making naked mole rats a highly relevant model for biological research. However, their living conditions in controlled environments do not allow them to express fundamental behaviours: digging galleries and exploring.

Spirituality, Self-Efficacy, and Medication Use in African American Women with Hypertension: Beyond the Prescriptions.

This study aimed to determine the relationship between spiritual, religious, and existential well-being and self-efficacy for appropriate medication use in African American women with hypertension. In this study, we conducted cross-sectional correlations using linear regression analysis. An African American sample of women from across the United States with hypertension was chosen through a purposive sampling technique.

Biflavonoid Methylchamaejasmin and Khaya grandifoliola Extract Inhibit NLRP3 Inflammasome in THP-1 Cell Model of Neuroinflammation.

Neuroinflammation is a common hallmark of Alzheimer's disease (AD), with NLRP3 inflammasome proven to be activated in microglia of AD patients' brains. In this study, a newly isolated biflavonoid (7,7'-di-O-methylchamaejasmin/M8) and a crude extract of the plant Khaya grandifoliola (KG) were investigated for their inhibitory effect on inflammasome activation. In preliminary experiments, M8 and KG showed no cytotoxicity on human macrophage-like differentiated THP-1 cells and exhibited anti-inflammatory inhibition of nitric oxide produced following lipopolysaccharide stimulation.

Pulsed Laser Ablation of Oxygen deficiency Enriched Superlattice Vanadium Pentoxide (VO) Ultrathin Nextrode aiming for Flexible Binder-less Tandem Energy Harvesting Devices.

For the initial instance, oxygen deficiency-enriched vanadium pentoxide (O─VO@500) thin film electrodes are tuned by the Pulsed Laser Ablation technique. The O─VO@500 thin film electrode shows remarkable electrochemical performances confirming the greater potential window of -0.4 to 0.

Exploring the relationship between dietary patterns and obesity among Nigerian adults: a cross-sectional study.

Background/objective: No previous study has investigated the association between dietary pattern and both general and abdominal obesity risk among adults in Nigeria. This study aimed to evaluate the associations between dietary patterns and the risk of obesity among adult age 18 and above in Ekiti State, Southwestern Nigeria.

Methods And Study Designs: A total of 1003 adults were included in this cross-sectional study (males = 558; females = 445).

Immune Activation in Alzheimer Disease.

Alzheimer disease (AD) is the most common neurodegenerative disease, and with no efficient curative treatment available, its medical, social, and economic burdens are expected to dramatically increase. AD is historically characterized by amyloid β (Aβ) plaques and tau neurofibrillary tangles, but over the last 25 years chronic immune activation has been identified as an important factor contributing to AD pathogenesis. In this article, we review recent and important advances in our understanding of the significance of immune activation in the development of AD.

Case Management in Prevention of 30-Day Readmission in Post-Coronary Artery Bypass Graft Surgery.

Purpose Of Study: Thirty-day readmission is associated with increased morbidity and mortality among postoperative coronary artery bypass graft (CABG) surgery patients. Interventions such as case management and follow-up care may reduce 30-day readmission. The purpose of this article is to report a study on modifiable factors that may have significant implications for case management in the prevention of readmission after CABG surgery.

Can Small Molecules Provide Clues on Disease Progression in Cerebrospinal Fluid from Mild Cognitive Impairment and Alzheimer's Disease Patients?

Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease, which is currently diagnosed via clinical symptoms and nonspecific biomarkers (such as Aβ, t-Tau, and p-Tau) measured in cerebrospinal fluid (CSF), which alone do not provide sufficient insights into disease progression. In this pilot study, these biomarkers were complemented with small-molecule analysis using non-target high-resolution mass spectrometry coupled with liquid chromatography (LC) on the CSF of three groups: AD, mild cognitive impairment (MCI) due to AD, and a non-demented (ND) control group. An open-source cheminformatics pipeline based on MS-DIAL and patRoon was enhanced using CSF- and AD-specific suspect lists to assist in data interpretation.

Distribution and antibiotic resistance of vibrio population in an urbanized tropical lake-the Vembanad-in the southwest coast of India.

Among the diverse Vibrio spp. autochthonous to coastal ecosystems, V. cholerae, V.

Perspective of Artificial Intelligence in Disease Diagnosis: A Review of Current and Future Endeavours in the Medical Field.

Artificial intelligence (AI) has demonstrated significant promise for the present and future diagnosis of diseases. At the moment, AI-powered diagnostic technologies can help physicians decipher medical pictures like X-rays, magnetic resonance imaging, and computed tomography scans, resulting in quicker and more precise diagnoses. In order to make a prospective diagnosis, AI algorithms may also examine patient information, symptoms, and medical background.

Perceptions of midwifery students and their lecturers regarding challenges faced by deaf pregnant women in accessing maternity care.

Midwives are central to caring for pregnant women in labour, including Deaf women. It is the midwife's responsibility to communicate and establish a relationship with the pregnant woman in labour, despite the accompanying challenges. Explore fourth-year undergraduate Midwifery Students' and their Lecturers' perceptions of the challenges faced by Deaf pregnant women in accessing maternity health care when in labour.

Effect of cognitive reserve on the association between slow wave sleep and cognition in community-dwelling older adults.

Sleep, especially slow wave sleep (SWS), is essential for cognitive functioning and is reduced in aging. The impact of sleep quality on cognition is variable, especially in aging. Cognitive reserve (CR) may be an important modulator of these effects.

GastroNet: A Custom Deep Learning Approach for Classification of Anomalies in Gastrointestinal Endoscopy Images.

Introduction: Among all cancer forms, gastrointestinal (GI) cancer is the most serious condition that spreads quickly and requires early detection. GI disorders claim the lives of up to nearly two million people worldwide. To lower the mortality rate from GI cancer, early detection is essential.

Analysis of the Six Sigma Principle in Pre-analytical Quality for Hematological Specimens.

Introduction Blood tests are essential for detecting and treating hospitalized individuals with diseases. Laboratory blood tests provide doctors with critical information required to treat their patient's illnesses. The most common sources of error in clinical laboratories are pre-analytical errors.

Sleep and memory consolidation in aging: A neuroimaging perspective.

Recently acquired information is strengthened and consolidated during sleep. For hippocampus-dependent memory, this process is assumed to occur mainly during slow wave sleep. Changes in sleep patterns in older adults can contribute to the disruption of the consolidation process during sleep and thus lead to cognitive impairment.

Recommendations to improve maternal health equity among Black women in "The South": A position paper from the SNRS minority health research interest & implementation group.

Black women in the United States experience a higher maternal mortality rate compared to other racial groups. The maternal mortality rate among non-Hispanic Black women is 3.5 times that of non-Hispanic White women and is higher in the South compared to other regions.

[First French-speaking days of users of decision support system in clinical pharmacy: Feedback and perspectives].

Clinical decision support systems (CDSS) are tools that have been used for several years by clinical pharmacy teams to support pharmaceutical analysis, with a perspective of contributing to the quality of care in collaboration with the other health care team members. These tools require both technical, logistical and human resources. The growing use of these systems in different establishments in France and in Europe gave birth to the idea of meeting to share our experiences.

Knowledge and Attitudes towards COVID-19 Infection and Anxiety Levels of Nigerian Youths Regarding the COVID-19 Pandemic.

Objectives: Youths can function as agents of change by disseminating essential information, but they are also considered a vulnerable group in the COVID-19 pandemic. Literature on COVID-related knowledge, attitude, and anxiety has not focused comprehensively on youths. This study assesses the knowledge, attitudes, and anxiety level of youths in eastern Nigeria during the COVID-19 pandemic.

Outcome of children with IgA vasculitis with nephritis treated with steroids: a matched controlled study.

Background: IgA vasculitis (IgAV) is the most common vasculitis in children. IgAV long-term prognosis depends on kidney involvement or IgA vasculitis with nephritis (IgAVN). To date, steroid treatment (oral steroids or methylprednisolone pulses) has not proven to be formally efficient.

Penicilliosis in a Non-HIV Patient: A Case Report.

A 68-year-old female, with a known case of mantle cell lymphoma, came with complaints of persistent cough with expectoration for three months, not responding to multiple courses of antibiotics. Bronchoscopy was done and bronchoalveolar lavage (BAL) culture revealed species. She was started on IV liposomal amphotericin B for 14 days and then switched to oral itraconazole which showed a response to treatment.

Distinct Sleep Alterations in Alcohol Use Disorder Patients with and without Korsakoff's Syndrome: Relationship with Episodic Memory.

Alcohol Use Disorder (AUD) results in sleep disturbances that may have deleterious impacts on cognition, especially on memory. However, little is known about the sleep architecture in patients with Korsakoff's syndrome (KS). This study aims at characterizing sleep disturbances in KS compared to AUD without KS and at specifying the relationships with cognitive impairments.