Publications by authors named "Marwan M Merkhan"
The Human Mesenchymal Stem Cell (hMSC) secretome has pleiotropic effects underpinning its therapeutic potential. hMSC serum-free conditioned media (SFCM) contains a variety of cytokines, with previous studies linking a changed secretome composition to physoxia. The Jurkat T cell model allowed the efficacy of SFCM vs.
View Article and Find Full Text PDFThe human mesenchymal stem cell (hMSC) secretome has pleiotropic effects which underpin their therapeutic potential. hMSC serum-free conditioned media (SFCM) has been determined to contain a variety of cytokines with roles in regeneration and suppression of inflammation. Physiological oxygen (physoxia) has been demonstrated to impact upon a number of facets of hMSC biology and we hypothesized that the secretome would be similarly modified.
View Article and Find Full Text PDFPlacental membrane-derived mesenchymal stem cells (MSCs), with the advantages of being non-invasive and having fewer ethical issues, are a promising source for cell therapy. Gestational diabetes (GDM) alters the uterine environment and may affect the therapeutic potential of MSCs derived from placenta. Therefore, we evaluated the biological properties of amniotic (AMSCs) and chorionic membrane MSCs (CMSCs) from human GDM placenta in order to explore their therapeutic potential.
View Article and Find Full Text PDFArticle Synopsis
- The study assessed the prevalence of metabolic syndrome in hypertensive type 2 diabetic patients on antihypertensive drugs that inhibit the renin-angiotensin system.
- Two groups of patients were compared: one group of 130 patients on specific medications and another group of 92 normotensive patients.
- Results showed that metabolic syndrome was less common in the treatment group (58.47%) compared to the control group (73%), indicating that the medications used may have beneficial effects in managing metabolic syndrome in these patients.