Publications by authors named "Marwa Saeed Hany"
Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3-d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line.
Ashraf Hassan Abadi Marwa Saeed Hany Shimaa Awadain Elsharif Amal Abdel Haleem Eissa Bernard Dewayne Gary
Chem Pharm Bull (Tokyo)
October 2013
Article Synopsis
- Researchers synthesized new chemical compounds based on two types of scaffolds: 3-cyano-4-alkoxyphenyl-6-bromoaryl-2-pyridone and 2-amino-3-cyano-4-alkoxyphenyl-6-bromoarylpyridine.
- The process involved cyclization with formic acid and formamide, resulting in two new types of derivatives that can inhibit phosphodiesterase 3 (PDE3).
- These compounds not only showed the ability to inhibit PDE3 but also demonstrated selective effects on hydrolysis of cAMP and cGMP, suggesting potential for targeted drug development with fewer side effects, such as tachycardia, and effectiveness against HT-29